CRB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CRB2 at tissue level.

III. Associated gene sets

GO_0030010Biological processestablishment of cell polarity
GO_0007601Biological processvisual perception
GO_0001895Biological processretina homeostasis
GO_0045199Biological processmaintenance of epithelial cell apical/basal polarity
GO_0010951Biological processnegative regulation of endopeptidase activity
GO_0045494Biological processphotoreceptor cell maintenance
GO_0010470Biological processregulation of gastrulation
GO_0072359Biological processcirculatory system development
GO_0055111Biological processingression involved in gastrulation with mouth forming second
GO_0046549Biological processretinal cone cell development
GO_0001707Biological processmesoderm formation
GO_0014028Biological processnotochord formation
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0001756Biological processsomitogenesis
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0045197Biological processestablishment or maintenance of epithelial cell apical/basal polarity
GO_0016324Cellular componentapical plasma membrane
GO_0035003Cellular componentsubapical complex
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0043296Cellular componentapical junction complex
GO_0005737Cellular componentcytoplasm
GO_0016327Cellular componentapicolateral plasma membrane
GO_0044877Molecular functionprotein-containing complex binding
GO_0019828Molecular functionaspartic-type endopeptidase inhibitor activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCRB2
Protein nameProtein crumbs homolog 2 (Crumbs-like protein 2)
Synonyms
DescriptionFUNCTION: Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (By similarity). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (By similarity). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB (By similarity). Plays a role in the maintenance of retinal neuroepithelium organization, structural integrity, adhesion, photoreceptor polarity and retinal photoreceptor layer thickness (By similarity). May play a role in determining the length of cone photoreceptor outer segments and proliferation of late-born progenitor cells (By similarity). Also required for maintenance of the apical polarity complex during development of the cortex (By similarity). Inhibits gamma-secretase-dependent cleavage of APP and secretion of amyloid-beta peptide 40 and amyloid-beta peptide 42, and thereby inhibits gamma-secretase-dependent Notch transcription . .

AccessionsQ5IJ48
ENST00000359999.7 [Q5IJ48-2]
ENST00000373631.8 [Q5IJ48-1]
ENST00000460253.1 [Q5IJ48-3]