Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 21 studies | 43% ± 12% | |
astrocyte | 15 studies | 41% ± 19% | |
microglial cell | 13 studies | 51% ± 15% | |
glutamatergic neuron | 12 studies | 58% ± 24% | |
fibroblast | 12 studies | 36% ± 13% | |
GABAergic neuron | 11 studies | 51% ± 23% | |
macrophage | 11 studies | 51% ± 23% | |
oligodendrocyte precursor cell | 11 studies | 42% ± 16% | |
oligodendrocyte | 11 studies | 40% ± 13% | |
pericyte | 9 studies | 34% ± 13% | |
myeloid cell | 9 studies | 38% ± 19% | |
epithelial cell | 9 studies | 36% ± 20% | |
adipocyte | 9 studies | 40% ± 12% | |
mast cell | 9 studies | 33% ± 11% | |
smooth muscle cell | 9 studies | 32% ± 10% | |
dendritic cell | 7 studies | 44% ± 14% | |
endothelial cell of lymphatic vessel | 7 studies | 46% ± 15% | |
B cell | 6 studies | 34% ± 12% | |
ciliated cell | 6 studies | 29% ± 10% | |
T cell | 6 studies | 33% ± 9% | |
basal cell | 6 studies | 43% ± 23% | |
non-classical monocyte | 5 studies | 23% ± 7% | |
neuron | 5 studies | 52% ± 21% | |
retinal cone cell | 5 studies | 32% ± 13% | |
cardiac muscle cell | 5 studies | 30% ± 8% | |
monocyte | 5 studies | 61% ± 6% | |
interneuron | 5 studies | 64% ± 18% | |
classical monocyte | 4 studies | 22% ± 1% | |
plasma cell | 4 studies | 28% ± 5% | |
mesothelial cell | 4 studies | 33% ± 8% | |
amacrine cell | 4 studies | 44% ± 13% | |
retina horizontal cell | 4 studies | 41% ± 18% | |
retinal ganglion cell | 4 studies | 48% ± 23% | |
retinal rod cell | 4 studies | 41% ± 10% | |
natural killer cell | 4 studies | 32% ± 7% | |
type I pneumocyte | 4 studies | 40% ± 10% | |
type II pneumocyte | 4 studies | 36% ± 9% | |
goblet cell | 4 studies | 36% ± 32% | |
hematopoietic precursor cell | 3 studies | 35% ± 24% | |
CD4-positive, alpha-beta T cell | 3 studies | 32% ± 1% | |
CD8-positive, alpha-beta T cell | 3 studies | 29% ± 5% | |
mononuclear phagocyte | 3 studies | 39% ± 14% | |
vein endothelial cell | 3 studies | 44% ± 24% | |
GABAergic amacrine cell | 3 studies | 47% ± 15% | |
Mueller cell | 3 studies | 43% ± 13% | |
glycinergic amacrine cell | 3 studies | 38% ± 13% | |
endothelial cell of vascular tree | 3 studies | 46% ± 21% | |
retinal pigment epithelial cell | 3 studies | 37% ± 28% | |
ependymal cell | 3 studies | 42% ± 17% | |
alveolar macrophage | 3 studies | 65% ± 10% | |
capillary endothelial cell | 3 studies | 31% ± 7% | |
club cell | 3 studies | 42% ± 10% | |
lymphocyte | 3 studies | 47% ± 18% | |
leukocyte | 3 studies | 54% ± 6% | |
transit amplifying cell | 3 studies | 43% ± 35% | |
granule cell | 3 studies | 51% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2158.42 | 459 / 459 | 100% | 56.67 | 1118 / 1118 |
esophagus | 100% | 1785.23 | 1445 / 1445 | 100% | 42.96 | 183 / 183 |
intestine | 100% | 1996.64 | 966 / 966 | 100% | 43.31 | 527 / 527 |
ovary | 100% | 1304.71 | 180 / 180 | 100% | 42.74 | 430 / 430 |
stomach | 100% | 1464.29 | 359 / 359 | 100% | 40.33 | 286 / 286 |
uterus | 100% | 1856.43 | 170 / 170 | 100% | 49.25 | 459 / 459 |
thymus | 100% | 1828.27 | 653 / 653 | 100% | 36.20 | 604 / 605 |
lung | 100% | 2011.50 | 578 / 578 | 100% | 46.50 | 1153 / 1155 |
bladder | 100% | 2073.95 | 21 / 21 | 100% | 49.68 | 503 / 504 |
prostate | 100% | 1629.08 | 245 / 245 | 100% | 33.10 | 501 / 502 |
brain | 99% | 1275.18 | 2626 / 2642 | 100% | 33.74 | 705 / 705 |
liver | 100% | 1113.94 | 225 / 226 | 100% | 36.83 | 405 / 406 |
pancreas | 100% | 1210.27 | 327 / 328 | 99% | 39.53 | 177 / 178 |
kidney | 100% | 1305.35 | 89 / 89 | 99% | 23.77 | 890 / 901 |
skin | 100% | 2531.80 | 1809 / 1809 | 98% | 36.31 | 461 / 472 |
adrenal gland | 100% | 1470.99 | 258 / 258 | 94% | 19.09 | 217 / 230 |
adipose | 100% | 2148.82 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 45.50 | 29 / 29 |
spleen | 100% | 2249.68 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 38.42 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 23.10 | 1 / 1 |
blood vessel | 100% | 1763.71 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 1317.85 | 802 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 3145.15 | 918 / 929 | 0% | 0 | 0 / 0 |
heart | 96% | 1053.33 | 830 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 93% | 19.20 | 74 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032436 | Biological process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0016567 | Biological process | protein ubiquitination |
GO_0010212 | Biological process | response to ionizing radiation |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0031464 | Cellular component | Cul4A-RING E3 ubiquitin ligase complex |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | COP1 |
Protein name | Ring finger and WD repeat domain 2 isoform I COP1 E3 ubiquitin ligase Ring finger and WD repeat domain 2 isoform B Ring finger and WD repeat domain 2 isoform H Ring finger and WD repeat domain 2 isoform G Ring finger and WD repeat domain 2 isoform D Ring finger and WD repeat domain 2 isoform C Ring finger and WD repeat domain 2 isoform F RFWD2 protein E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) |
Synonyms | RFWD2 RNF200 |
Description | FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable). . |
Accessions | X5D2S9 ENST00000649803.1 X5D7W8 Q05CT6 ENST00000498306.5 ENST00000491600.5 X5DR91 ENST00000367669.8 [Q8NHY2-1] H0YF49 E9PJB5 ENST00000474194.1 [Q8NHY2-5] ENST00000308769.12 [Q8NHY2-2] ENST00000459744.5 X5D7N8 H0Y339 ENST00000367666.5 Q8NHY2 E9PMW8 A0A3B3ISQ9 X5DRD4 H0Y340 ENST00000367667.5 X5D9B8 X5DNY7 |