CERS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0035902Biological processresponse to immobilization stress
GO_1900148Biological processnegative regulation of Schwann cell migration
GO_0048681Biological processnegative regulation of axon regeneration
GO_0019216Biological processregulation of lipid metabolic process
GO_0046513Biological processceramide biosynthetic process
GO_1905045Biological processnegative regulation of Schwann cell proliferation involved in axon regeneration
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0003677Molecular functionDNA binding
GO_0050291Molecular functionsphingosine N-acyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCERS2
Protein nameCeramide synthase 2
Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297)
SynonymsLASS2
TMSG1
DescriptionFUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) . N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (By similarity) . Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (By similarity). .

AccessionsENST00000560793.6
H0YLQ6
Q5SZE4
Q5SZE1
ENST00000558062.5
ENST00000368954.10
Q96G23
ENST00000368949.8
ENST00000457392.1
H0YKH6
ENST00000361419.9
Q5SZE2
ENST00000561294.5
H0YNU7
ENST00000271688.10
ENST00000421609.5
Q5SZE3