Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 37 studies | 48% ± 21% | |
pericyte | 27 studies | 36% ± 20% | |
astrocyte | 19 studies | 57% ± 19% | |
fibroblast | 19 studies | 37% ± 16% | |
smooth muscle cell | 17 studies | 35% ± 16% | |
oligodendrocyte | 16 studies | 69% ± 18% | |
oligodendrocyte precursor cell | 16 studies | 59% ± 22% | |
endothelial cell of lymphatic vessel | 14 studies | 40% ± 20% | |
glutamatergic neuron | 13 studies | 70% ± 20% | |
endothelial cell of artery | 13 studies | 33% ± 16% | |
GABAergic neuron | 11 studies | 68% ± 20% | |
capillary endothelial cell | 10 studies | 32% ± 15% | |
epithelial cell | 10 studies | 32% ± 12% | |
ciliated cell | 10 studies | 27% ± 12% | |
basal cell | 9 studies | 32% ± 16% | |
adipocyte | 9 studies | 42% ± 14% | |
neuron | 8 studies | 54% ± 21% | |
amacrine cell | 8 studies | 42% ± 17% | |
interneuron | 7 studies | 67% ± 26% | |
retinal ganglion cell | 7 studies | 77% ± 19% | |
club cell | 7 studies | 37% ± 15% | |
myofibroblast cell | 6 studies | 32% ± 14% | |
microglial cell | 6 studies | 53% ± 18% | |
retina horizontal cell | 6 studies | 69% ± 18% | |
retinal cone cell | 6 studies | 51% ± 19% | |
mesothelial cell | 6 studies | 39% ± 22% | |
vein endothelial cell | 6 studies | 36% ± 21% | |
type I pneumocyte | 6 studies | 41% ± 13% | |
type II pneumocyte | 6 studies | 35% ± 10% | |
respiratory goblet cell | 5 studies | 46% ± 19% | |
retinal bipolar neuron | 5 studies | 36% ± 14% | |
cardiac muscle cell | 5 studies | 53% ± 14% | |
Mueller cell | 5 studies | 44% ± 17% | |
endothelial cell of vascular tree | 5 studies | 44% ± 24% | |
secretory cell | 4 studies | 28% ± 9% | |
glial cell | 4 studies | 39% ± 13% | |
granule cell | 4 studies | 67% ± 9% | |
macrophage | 4 studies | 36% ± 15% | |
retinal pigment epithelial cell | 4 studies | 36% ± 26% | |
OFF-bipolar cell | 4 studies | 56% ± 21% | |
ON-bipolar cell | 4 studies | 60% ± 23% | |
retinal rod cell | 4 studies | 44% ± 12% | |
hepatocyte | 4 studies | 56% ± 14% | |
muscle cell | 4 studies | 39% ± 28% | |
connective tissue cell | 4 studies | 39% ± 11% | |
goblet cell | 4 studies | 33% ± 24% | |
endothelial cell of sinusoid | 3 studies | 28% ± 13% | |
glomerular endothelial cell | 3 studies | 25% ± 1% | |
renal alpha-intercalated cell | 3 studies | 28% ± 11% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 61% ± 9% | |
GABAergic interneuron | 3 studies | 77% ± 4% | |
progenitor cell | 3 studies | 42% ± 10% | |
endocardial cell | 3 studies | 41% ± 18% | |
GABAergic amacrine cell | 3 studies | 60% ± 13% | |
glycinergic amacrine cell | 3 studies | 50% ± 9% | |
rod bipolar cell | 3 studies | 44% ± 19% | |
neural progenitor cell | 3 studies | 37% ± 15% | |
ependymal cell | 3 studies | 59% ± 15% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 27% ± 7% | |
alveolar macrophage | 3 studies | 20% ± 2% | |
chondrocyte | 3 studies | 51% ± 20% | |
transit amplifying cell | 3 studies | 36% ± 27% | |
mast cell | 3 studies | 21% ± 6% | |
mucus secreting cell | 3 studies | 44% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 6133.74 | 245 / 245 | 99% | 20.30 | 499 / 502 |
brain | 100% | 6919.24 | 2642 / 2642 | 99% | 20.19 | 698 / 705 |
pancreas | 100% | 2382.84 | 327 / 328 | 97% | 25.69 | 173 / 178 |
esophagus | 100% | 5136.41 | 1439 / 1445 | 97% | 23.97 | 178 / 183 |
ovary | 100% | 4965.32 | 180 / 180 | 96% | 14.81 | 412 / 430 |
kidney | 100% | 4460.90 | 89 / 89 | 96% | 19.00 | 862 / 901 |
lung | 100% | 4938.95 | 578 / 578 | 96% | 18.50 | 1105 / 1155 |
stomach | 100% | 4932.77 | 359 / 359 | 95% | 18.53 | 273 / 286 |
adrenal gland | 100% | 4601.18 | 258 / 258 | 94% | 20.30 | 217 / 230 |
intestine | 100% | 6598.58 | 966 / 966 | 94% | 14.24 | 497 / 527 |
breast | 100% | 4998.58 | 459 / 459 | 94% | 19.84 | 1054 / 1118 |
skin | 99% | 3293.60 | 1788 / 1809 | 94% | 19.92 | 444 / 472 |
thymus | 100% | 3271.14 | 651 / 653 | 92% | 9.98 | 555 / 605 |
uterus | 100% | 6199.41 | 170 / 170 | 87% | 12.58 | 401 / 459 |
bladder | 100% | 8757.33 | 21 / 21 | 86% | 10.25 | 432 / 504 |
liver | 99% | 2324.61 | 224 / 226 | 86% | 11.19 | 348 / 406 |
adipose | 100% | 5691.54 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6708.85 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.16 | 1 / 1 |
heart | 100% | 3628.94 | 860 / 861 | 0% | 0 | 0 / 0 |
muscle | 100% | 2555.46 | 801 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2363.02 | 240 / 241 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 13.59 | 71 / 80 |
tonsil | 0% | 0 | 0 / 0 | 64% | 6.26 | 29 / 45 |
peripheral blood | 9% | 296.20 | 83 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0018107 | Biological process | peptidyl-threonine phosphorylation |
GO_0031032 | Biological process | actomyosin structure organization |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0006468 | Biological process | protein phosphorylation |
GO_0016477 | Biological process | cell migration |
GO_0005856 | Cellular component | cytoskeleton |
GO_0070062 | Cellular component | extracellular exosome |
GO_0031252 | Cellular component | cell leading edge |
GO_0005911 | Cellular component | cell-cell junction |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0042641 | Cellular component | actomyosin |
GO_0030027 | Cellular component | lamellipodium |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CDC42BPA |
Protein name | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) non-specific serine/threonine protein kinase (EC 2.7.11.1) |
Synonyms | KIAA0451 |
Description | FUNCTION: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration . Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 . In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration . Phosphorylates: PPP1R12A, LIMK1 and LIMK2 . May play a role in TFRC-mediated iron uptake . In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells . . |
Accessions | Q5VT25 ENST00000366764.8 ENST00000366766 ENST00000448940.5 B9EGA7 H0Y7V8 H0Y5V1 ENST00000366766.8 [Q5VT25-2] ENST00000366769.7 [Q5VT25-5] ENST00000441725.1 ENST00000442054.5 H0Y6R0 A0A0A0MRJ0 A0A0A0MRJ1 A0A8I5QJM2 ENST00000429440.5 ENST00000366767.7 [Q5VT25-3] ENST00000334218.9 [Q5VT25-1] |