CD160 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD160 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0045954Biological processpositive regulation of natural killer cell mediated cytotoxicity
GO_0002385Biological processmucosal immune response
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0045087Biological processinnate immune response
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0031295Biological processT cell costimulation
GO_0002729Biological processpositive regulation of natural killer cell cytokine production
GO_0016525Biological processnegative regulation of angiogenesis
GO_0002857Biological processpositive regulation of natural killer cell mediated immune response to tumor cell
GO_0002250Biological processadaptive immune response
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0032729Biological processpositive regulation of type II interferon production
GO_1905675Biological processnegative regulation of adaptive immune memory response
GO_2000353Biological processpositive regulation of endothelial cell apoptotic process
GO_1900280Biological processnegative regulation of CD4-positive, alpha-beta T cell costimulation
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0098552Cellular componentside of membrane
GO_0019900Molecular functionkinase binding
GO_0032393Molecular functionMHC class I receptor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0023024Molecular functionMHC class I protein complex binding
GO_0032397Molecular functionactivating MHC class I receptor activity
GO_0032394Molecular functionMHC class Ib receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD160
Protein nameCD160 antigen (CD160 molecule) (CD160 protein)
CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]
SynonymshCG_1762288
BY55
RP11-373C9.1-006
DescriptionFUNCTION: [CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells . Receptor for both classical and non-classical MHC class I molecules . In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response . On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells . Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion . On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites . Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response . In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). .; FUNCTION: [CD160 antigen, soluble form]: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions. .

AccessionsENST00000235933.10 [O95971-1]
ENST00000369288.7 [O95971-1]
O95971
Q6FH89
ENST00000616463.1 [O95971-4]
ENST00000401557.7 [O95971-3]
ENST00000584442.2 [O95971-2]