CCNK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	13 studies	20% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	21% ± 4%	Explore
naive B cell	7 studies	17% ± 2%	Explore
classical monocyte	6 studies	25% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	20% ± 2%	Explore
CD8-positive, alpha-beta T cell	6 studies	19% ± 4%	Explore
epithelial cell	6 studies	32% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	19% ± 3%	Explore
T cell	5 studies	17% ± 1%	Explore
endothelial cell	5 studies	23% ± 5%	Explore
mucosal invariant T cell	5 studies	19% ± 1%	Explore
regulatory T cell	5 studies	19% ± 1%	Explore
gamma-delta T cell	5 studies	24% ± 5%	Explore
B cell	4 studies	19% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	16% ± 1%	Explore
non-classical monocyte	4 studies	31% ± 10%	Explore
CD4-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
memory B cell	4 studies	16% ± 1%	Explore
fibroblast	4 studies	17% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
mature NK T cell	3 studies	17% ± 1%	Explore
microglial cell	3 studies	16% ± 1%	Explore
ciliated cell	3 studies	26% ± 7%	Explore
GABAergic neuron	3 studies	25% ± 4%	Explore
glutamatergic neuron	3 studies	32% ± 5%	Explore
dendritic cell	3 studies	35% ± 15%	Explore
abnormal cell	3 studies	16% ± 0%	Explore
goblet cell	3 studies	30% ± 15%	Explore
basal cell	3 studies	26% ± 8%	Explore
plasmacytoid dendritic cell	3 studies	22% ± 6%	Explore
double negative thymocyte	3 studies	24% ± 5%	Explore
astrocyte	3 studies	21% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	5 studies	22% ± 6%	Explore
brain	5 studies	23% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	362.32	1441 / 1445	100%	5.86	183 / 183
stomach	100%	322.95	358 / 359	99%	4.71	282 / 286
lung	100%	475.24	578 / 578	98%	3.96	1134 / 1155
intestine	100%	390.50	966 / 966	98%	3.98	514 / 527
ovary	100%	517.65	180 / 180	97%	4.37	419 / 430
skin	100%	564.20	1808 / 1809	96%	3.40	452 / 472
breast	100%	422.45	459 / 459	94%	3.62	1047 / 1118
pancreas	99%	208.44	324 / 328	93%	2.66	165 / 178
bladder	100%	344.81	21 / 21	89%	3.00	450 / 504
brain	94%	187.02	2493 / 2642	94%	2.76	664 / 705
prostate	100%	326.25	245 / 245	87%	2.37	435 / 502
uterus	100%	418.23	170 / 170	84%	2.87	386 / 459
thymus	100%	450.68	652 / 653	84%	2.35	509 / 605
kidney	100%	290.55	89 / 89	80%	1.79	722 / 901
adrenal gland	100%	336.12	258 / 258	65%	1.39	150 / 230
liver	87%	131.87	196 / 226	47%	0.84	192 / 406
adipose	100%	430.53	1204 / 1204	0%	0	0 / 0
spleen	100%	315.55	241 / 241	0%	0	0 / 0
blood vessel	100%	351.95	1334 / 1335	0%	0	0 / 0
muscle	100%	464.76	802 / 803	0%	0	0 / 0
peripheral blood	99%	622.90	921 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	96%	2.75	77 / 80
heart	94%	243.61	807 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	87%	2.98	39 / 45
lymph node	0%	0	0 / 0	59%	2.85	17 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0009966	Biological process	regulation of signal transduction
GO_0032786	Biological process	positive regulation of DNA-templated transcription, elongation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000079	Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0006974	Biological process	DNA damage response
GO_0051301	Biological process	cell division
GO_0044828	Biological process	negative regulation by host of viral genome replication
GO_0032968	Biological process	positive regulation of transcription elongation by RNA polymerase II
GO_0002944	Cellular component	cyclin K-CDK12 complex
GO_0008024	Cellular component	cyclin/CDK positive transcription elongation factor complex
GO_0002945	Cellular component	cyclin K-CDK13 complex
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0061575	Molecular function	cyclin-dependent protein serine/threonine kinase activator activity
GO_0019901	Molecular function	protein kinase binding
GO_0008353	Molecular function	RNA polymerase II CTD heptapeptide repeat kinase activity
GO_0005515	Molecular function	protein binding
GO_0004693	Molecular function	cyclin-dependent protein serine/threonine kinase activity

IV. Literature review

[source]

Gene name	CCNK
Protein name	Cyclin K Cyclin-K
Synonyms	CPR4
Description	FUNCTION: Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). .
Accessions	O75909 G3V235 G3V2Q3 G3V5E1 ENST00000389879.9 [O75909-3] ENST00000555842.1 ENST00000557441.5 ENST00000555049.5

CCNK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review