CBR4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044597Biological processdaunorubicin metabolic process
GO_0006633Biological processfatty acid biosynthetic process
GO_0044598Biological processdoxorubicin metabolic process
GO_0051290Biological processprotein heterotetramerization
GO_0051289Biological processprotein homotetramerization
GO_1990204Cellular componentoxidoreductase complex
GO_0005759Cellular componentmitochondrial matrix
GO_0004316Molecular function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO_0008753Molecular functionNADPH dehydrogenase (quinone) activity
GO_0070402Molecular functionNADPH binding
GO_0003955Molecular functionNAD(P)H dehydrogenase (quinone) activity
GO_0048038Molecular functionquinone binding
GO_0005515Molecular functionprotein binding
GO_0016616Molecular functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

IV. Literature review

[source]
Gene nameCBR4
Protein name3-ketoacyl-[acyl-carrier-protein] reductase beta subunit (Quinone reductase CBR4)
Carbonyl reductase 4
3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 45C member 1)
SynonymsSDR45C1
DescriptionFUNCTION: Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis . The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones . As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) . .

AccessionsENST00000504561.1
ENST00000306193.8 [Q8N4T8-1]
ENST00000506808.1
D6RAV8
H0Y962
D6RJF4
ENST00000507752.1
Q8N4T8
ENST00000504480.5 [Q8N4T8-2]
ENST00000510042.5
D6RGF2