CALCRL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0031623Biological processreceptor internalization
GO_1990410Biological processadrenomedullin receptor signaling pathway
GO_0007507Biological processheart development
GO_1990408Biological processcalcitonin gene-related peptide receptor signaling pathway
GO_1990874Biological processvascular associated smooth muscle cell proliferation
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0015031Biological processprotein transport
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0006816Biological processcalcium ion transport
GO_0071329Biological processcellular response to sucrose stimulus
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0005764Cellular componentlysosome
GO_1990406Cellular componentCGRP receptor complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_1903143Cellular componentadrenomedullin receptor complex
GO_0005768Cellular componentendosome
GO_0004930Molecular functionG protein-coupled receptor activity
GO_1990409Molecular functionadrenomedullin binding
GO_0001605Molecular functionadrenomedullin receptor activity
GO_0001635Molecular functioncalcitonin gene-related peptide receptor activity
GO_0004948Molecular functioncalcitonin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCALCRL
Protein nameCalcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
SynonymsCGRPR
DescriptionFUNCTION: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2 . The activity of this receptor is mediated by G proteins which activate adenylyl cyclase . .

FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. .

FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. .

AccessionsENST00000447403.5
ENST00000410068.5
E7EN01
Q16602
ENST00000410102.5
ENST00000409998.5
B8ZZJ4
ENST00000392370.8