BLK report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BLK at tissue level.

III. Associated gene sets

GO_0032092Biological processpositive regulation of protein binding
GO_0050853Biological processB cell receptor signaling pathway
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0035556Biological processintracellular signal transduction
GO_0006468Biological processprotein phosphorylation
GO_0030154Biological processcell differentiation
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0032024Biological processpositive regulation of insulin secretion
GO_0045087Biological processinnate immune response
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBLK
Protein nameTyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
Tyrosine-protein kinase (EC 2.7.10.2)
Synonyms
DescriptionFUNCTION: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C . With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose . Phosphorylates CGAS, promoting retention of CGAS in the cytosol . .

AccessionsP51451
ENST00000259089.9
Q05D26
ENST00000646615.3