Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 73% | 388.75 | 424 / 578 | 88% | 6.32 | 1021 / 1155 |
| intestine | 44% | 425.49 | 421 / 966 | 98% | 5.61 | 519 / 527 |
| esophagus | 38% | 553.84 | 554 / 1445 | 99% | 14.53 | 181 / 183 |
| brain | 65% | 1337.78 | 1709 / 2642 | 68% | 2.13 | 477 / 705 |
| skin | 72% | 3235.18 | 1310 / 1809 | 55% | 2.88 | 258 / 472 |
| bladder | 38% | 208.86 | 8 / 21 | 83% | 5.35 | 419 / 504 |
| stomach | 15% | 58.12 | 55 / 359 | 98% | 7.11 | 279 / 286 |
| thymus | 52% | 249.15 | 340 / 653 | 52% | 11.22 | 312 / 605 |
| spleen | 100% | 1252.10 | 240 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 10.83 | 44 / 45 |
| breast | 32% | 157.53 | 147 / 459 | 65% | 2.98 | 732 / 1118 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 10.22 | 26 / 29 |
| pancreas | 0% | 0 | 0 / 328 | 89% | 3.88 | 159 / 178 |
| uterus | 1% | 11.56 | 2 / 170 | 75% | 5.05 | 344 / 459 |
| kidney | 7% | 45.60 | 6 / 89 | 64% | 2.10 | 573 / 901 |
| peripheral blood | 65% | 765.84 | 604 / 929 | 0% | 0 | 0 / 0 |
| prostate | 20% | 82.64 | 49 / 245 | 39% | 0.85 | 194 / 502 |
| adrenal gland | 6% | 20.28 | 15 / 258 | 25% | 0.80 | 57 / 230 |
| liver | 1% | 4.11 | 3 / 226 | 20% | 0.55 | 80 / 406 |
| ovary | 0% | 0 | 0 / 180 | 20% | 0.45 | 86 / 430 |
| adipose | 14% | 59.29 | 172 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 13% | 0.29 | 10 / 80 |
| blood vessel | 3% | 19.51 | 43 / 1335 | 0% | 0 | 0 / 0 |
| heart | 0% | 1.41 | 3 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 1.15 | 2 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0045664 | Biological process | regulation of neuron differentiation |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0021773 | Biological process | striatal medium spiny neuron differentiation |
| GO_0003382 | Biological process | epithelial cell morphogenesis |
| GO_0033153 | Biological process | T cell receptor V(D)J recombination |
| GO_0019216 | Biological process | regulation of lipid metabolic process |
| GO_0043368 | Biological process | positive T cell selection |
| GO_0097535 | Biological process | lymphoid lineage cell migration into thymus |
| GO_0021902 | Biological process | commitment of neuronal cell to specific neuron type in forebrain |
| GO_0070242 | Biological process | thymocyte apoptotic process |
| GO_0071678 | Biological process | olfactory bulb axon guidance |
| GO_0033077 | Biological process | T cell differentiation in thymus |
| GO_0048538 | Biological process | thymus development |
| GO_0035701 | Biological process | hematopoietic stem cell migration |
| GO_0003334 | Biological process | keratinocyte development |
| GO_0070244 | Biological process | negative regulation of thymocyte apoptotic process |
| GO_0046632 | Biological process | alpha-beta T cell differentiation |
| GO_0010837 | Biological process | regulation of keratinocyte proliferation |
| GO_0031077 | Biological process | post-embryonic camera-type eye development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0016514 | Cellular component | SWI/SNF complex |
| GO_0043005 | Cellular component | neuron projection |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | BCL11B |
| Protein name | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) ATL1-alpha zinc finger protein (B-cell CLL/lymphoma 11B (Zinc finger protein), isoform CRA_b) BCL11 transcription factor B ATL1-gamma zinc finger protein (B-cell CLL/lymphoma 11B (Zinc finger protein), isoform CRA_a) |
| Synonyms | RIT1 CTIP2 hCG_1657560 ATL1-gamma ATL1-alpha |
| Description | FUNCTION: Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus . Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes . Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). . |
| Accessions | ENST00000443726.2 Q9C0K0 ENST00000357195.8 [Q9C0K0-1] L8B567 D3YTK1 L8B7P7 ENST00000345514.2 [Q9C0K0-2] |
