ATP6V1H report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006897Biological processendocytosis
GO_0048388Biological processendosomal lumen acidification
GO_0007042Biological processlysosomal lumen acidification
GO_0051452Biological processintracellular pH reduction
GO_0097401Biological processsynaptic vesicle lumen acidification
GO_0007035Biological processvacuolar acidification
GO_0061795Biological processGolgi lumen acidification
GO_0016241Biological processregulation of macroautophagy
GO_1902600Biological processproton transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_1902495Cellular componenttransmembrane transporter complex
GO_0070062Cellular componentextracellular exosome
GO_0033176Cellular componentproton-transporting V-type ATPase complex
GO_0000221Cellular componentvacuolar proton-transporting V-type ATPase, V1 domain
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0098850Cellular componentextrinsic component of synaptic vesicle membrane
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0030234Molecular functionenzyme regulator activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP6V1H
Protein nameV-type proton ATPase subunit H (V-ATPase subunit H) (Nef-binding protein 1) (NBP1) (Protein VMA13 homolog) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD)
ATPase H+ transporting V1 subunit H
V-type proton ATPase subunit H
SynonymshCG_27354
CGI-11
DescriptionFUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes . .

FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. .

AccessionsE5RJG1
ENST00000355221.7 [Q9UI12-2]
E5RK31
E5RG49
Q9UI12
ENST00000359530.7 [Q9UI12-1]
ENST00000519588.1
ENST00000522849.1
E5RHH0
ENST00000396774.6 [Q9UI12-1]
ENST00000521275.5
ENST00000520188.5
H0YB41
ENST00000524234.1
G3V126
ENST00000524164.5