Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 20 studies | 29% ± 14% | |
macrophage | 15 studies | 30% ± 12% | |
astrocyte | 13 studies | 42% ± 19% | |
microglial cell | 13 studies | 50% ± 16% | |
glutamatergic neuron | 12 studies | 50% ± 25% | |
fibroblast | 12 studies | 23% ± 5% | |
oligodendrocyte | 12 studies | 34% ± 13% | |
GABAergic neuron | 11 studies | 42% ± 22% | |
oligodendrocyte precursor cell | 11 studies | 38% ± 17% | |
ciliated cell | 10 studies | 23% ± 7% | |
epithelial cell | 9 studies | 35% ± 15% | |
adipocyte | 8 studies | 29% ± 7% | |
neuron | 7 studies | 41% ± 14% | |
pericyte | 7 studies | 27% ± 13% | |
dendritic cell | 7 studies | 26% ± 12% | |
endothelial cell of lymphatic vessel | 7 studies | 26% ± 7% | |
interneuron | 6 studies | 57% ± 21% | |
myeloid cell | 6 studies | 20% ± 4% | |
retina horizontal cell | 6 studies | 51% ± 19% | |
retinal cone cell | 6 studies | 27% ± 7% | |
monocyte | 6 studies | 33% ± 18% | |
type I pneumocyte | 6 studies | 25% ± 4% | |
type II pneumocyte | 6 studies | 38% ± 6% | |
amacrine cell | 5 studies | 26% ± 7% | |
cardiac muscle cell | 5 studies | 37% ± 12% | |
basal cell | 5 studies | 34% ± 13% | |
mast cell | 5 studies | 31% ± 14% | |
smooth muscle cell | 5 studies | 20% ± 4% | |
goblet cell | 5 studies | 27% ± 16% | |
granule cell | 4 studies | 31% ± 9% | |
retinal ganglion cell | 4 studies | 43% ± 10% | |
retinal pigment epithelial cell | 4 studies | 38% ± 16% | |
retinal rod cell | 4 studies | 29% ± 7% | |
connective tissue cell | 4 studies | 17% ± 1% | |
alveolar macrophage | 4 studies | 40% ± 17% | |
club cell | 4 studies | 23% ± 5% | |
hematopoietic precursor cell | 3 studies | 40% ± 13% | |
secretory cell | 3 studies | 17% ± 2% | |
GABAergic interneuron | 3 studies | 40% ± 4% | |
mesothelial cell | 3 studies | 25% ± 7% | |
GABAergic amacrine cell | 3 studies | 37% ± 13% | |
glycinergic amacrine cell | 3 studies | 26% ± 3% | |
endothelial cell of vascular tree | 3 studies | 29% ± 11% | |
natural killer cell | 3 studies | 31% ± 19% | |
respiratory goblet cell | 3 studies | 18% ± 2% | |
ependymal cell | 3 studies | 34% ± 15% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 45% ± 17% | |
T cell | 3 studies | 22% ± 5% | |
lymphocyte | 3 studies | 23% ± 5% | |
transit amplifying cell | 3 studies | 34% ± 22% | |
kidney loop of Henle epithelial cell | 3 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3836.26 | 1445 / 1445 | 100% | 68.66 | 183 / 183 |
prostate | 100% | 8177.70 | 245 / 245 | 100% | 159.73 | 502 / 502 |
lung | 100% | 6285.31 | 578 / 578 | 100% | 65.65 | 1154 / 1155 |
brain | 100% | 5645.96 | 2642 / 2642 | 100% | 50.66 | 704 / 705 |
breast | 100% | 5029.64 | 459 / 459 | 100% | 62.83 | 1116 / 1118 |
ovary | 100% | 4877.63 | 180 / 180 | 100% | 37.41 | 428 / 430 |
intestine | 100% | 4083.41 | 966 / 966 | 99% | 42.90 | 524 / 527 |
bladder | 100% | 4881.29 | 21 / 21 | 99% | 48.53 | 501 / 504 |
uterus | 100% | 4873.43 | 170 / 170 | 99% | 63.27 | 455 / 459 |
thymus | 100% | 4645.97 | 653 / 653 | 99% | 42.92 | 597 / 605 |
stomach | 100% | 3546.23 | 359 / 359 | 99% | 43.86 | 282 / 286 |
kidney | 100% | 3852.18 | 89 / 89 | 98% | 45.80 | 884 / 901 |
pancreas | 98% | 2383.85 | 323 / 328 | 99% | 46.26 | 176 / 178 |
skin | 100% | 6973.33 | 1809 / 1809 | 97% | 44.97 | 459 / 472 |
adrenal gland | 100% | 5157.16 | 258 / 258 | 97% | 33.42 | 223 / 230 |
liver | 98% | 1766.36 | 221 / 226 | 78% | 16.94 | 316 / 406 |
adipose | 100% | 4986.11 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 3221.82 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 76.66 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.52 | 1 / 1 |
blood vessel | 100% | 4257.40 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 2527.05 | 798 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 3324.38 | 841 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 20.48 | 26 / 29 |
eye | 0% | 0 | 0 / 0 | 81% | 19.52 | 65 / 80 |
peripheral blood | 70% | 2987.28 | 646 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006828 | Biological process | manganese ion transport |
GO_0008544 | Biological process | epidermis development |
GO_0042998 | Biological process | positive regulation of Golgi to plasma membrane protein transport |
GO_0006874 | Biological process | intracellular calcium ion homeostasis |
GO_0071421 | Biological process | manganese ion transmembrane transport |
GO_0032468 | Biological process | Golgi calcium ion homeostasis |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0032472 | Biological process | Golgi calcium ion transport |
GO_0016339 | Biological process | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
GO_0098629 | Biological process | trans-Golgi network membrane organization |
GO_0006816 | Biological process | calcium ion transport |
GO_0070588 | Biological process | calcium ion transmembrane transport |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005802 | Cellular component | trans-Golgi network |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0033106 | Cellular component | cis-Golgi network membrane |
GO_0032580 | Cellular component | Golgi cisterna membrane |
GO_0140613 | Molecular function | P-type manganese transporter activity |
GO_0005388 | Molecular function | P-type calcium transporter activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | ATP2C1 |
Protein name | Calcium-transporting ATPase type 2C member 1 (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) ATPase secretory pathway Ca2+ transporting 1 Calcium-transporting ATPase (EC 7.2.2.10) Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) |
Synonyms | hCG_14809 HUSSY-28 KIAA1347 PMR1L |
Description | FUNCTION: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway . Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state . Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology . Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity . Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity . . FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium. . |
Accessions | ENST00000508297.2 H0Y8X9 ENST00000513801.5 [P98194-3] ENST00000508660.5 ENST00000505072.5 ENST00000505330.5 D6RGE9 D6R9U9 H0YAH2 B4E2Q0 H0Y9V7 H0Y9S7 ENST00000422190.6 [P98194-5] ENST00000359644.7 [P98194-9] ENST00000504381.5 [P98194-8] ENST00000507488.6 [P98194-7] ENST00000533801.6 [P98194-2] ENST00000509662.5 D6RHV9 ENST00000507194.1 ENST00000510168.6 [P98194-1] ENST00000504612.5 ENST00000428331.6 [P98194-1] P98194 ENST00000508532.5 [P98194-1] D6REJ1 ENST00000504571.5 ENST00000504948.5 [P98194-4] ENST00000515854.5 ENST00000328560.12 [P98194-2] |