ATP2C1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006828Biological processmanganese ion transport
GO_0008544Biological processepidermis development
GO_0042998Biological processpositive regulation of Golgi to plasma membrane protein transport
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0071421Biological processmanganese ion transmembrane transport
GO_0032468Biological processGolgi calcium ion homeostasis
GO_0030036Biological processactin cytoskeleton organization
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0032472Biological processGolgi calcium ion transport
GO_0016339Biological processcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0098629Biological processtrans-Golgi network membrane organization
GO_0006816Biological processcalcium ion transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0033106Cellular componentcis-Golgi network membrane
GO_0032580Cellular componentGolgi cisterna membrane
GO_0140613Molecular functionP-type manganese transporter activity
GO_0005388Molecular functionP-type calcium transporter activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP2C1
Protein nameCalcium-transporting ATPase type 2C member 1 (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1)
ATPase secretory pathway Ca2+ transporting 1
Calcium-transporting ATPase (EC 7.2.2.10)
Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1)
SynonymshCG_14809
HUSSY-28
KIAA1347
PMR1L
DescriptionFUNCTION: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway . Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state . Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology . Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity . Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity . .

FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium. .

AccessionsENST00000508297.2
H0Y8X9
ENST00000513801.5 [P98194-3]
ENST00000508660.5
ENST00000505072.5
ENST00000505330.5
D6RGE9
D6R9U9
H0YAH2
B4E2Q0
H0Y9V7
H0Y9S7
ENST00000422190.6 [P98194-5]
ENST00000359644.7 [P98194-9]
ENST00000504381.5 [P98194-8]
ENST00000507488.6 [P98194-7]
ENST00000533801.6 [P98194-2]
ENST00000509662.5
D6RHV9
ENST00000507194.1
ENST00000510168.6 [P98194-1]
ENST00000504612.5
ENST00000428331.6 [P98194-1]
P98194
ENST00000508532.5 [P98194-1]
D6REJ1
ENST00000504571.5
ENST00000504948.5 [P98194-4]
ENST00000515854.5
ENST00000328560.12 [P98194-2]