ATIC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006139Biological processnucleobase-containing compound metabolic process
GO_0098761Biological processcellular response to interleukin-7
GO_0044208Biological process'de novo' AMP biosynthetic process
GO_0031100Biological processanimal organ regeneration
GO_0097294Biological process'de novo' XMP biosynthetic process
GO_0006177Biological processGMP biosynthetic process
GO_0046654Biological processtetrahydrofolate biosynthetic process
GO_0046452Biological processdihydrofolate metabolic process
GO_0003360Biological processbrainstem development
GO_0021549Biological processcerebellum development
GO_0021987Biological processcerebral cortex development
GO_0006189Biological process'de novo' IMP biosynthetic process
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0042803Molecular functionprotein homodimerization activity
GO_0045296Molecular functioncadherin binding
GO_0004643Molecular functionphosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO_0003937Molecular functionIMP cyclohydrolase activity

IV. Literature review

[source]
Gene nameATIC
Protein nameBifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase)
Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)]
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
SynonymsOK/SW-cl.86
PURH
DescriptionFUNCTION: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis . Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) . Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction . Also catalyzes the cyclization of FAICAR to IMP . Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias . Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization . .

AccessionsENST00000426233.1
ENST00000443953.5
ENST00000435675.5 [P31939-2]
F8WEF0
C9JLK0
F2Z3E8
P31939
ENST00000413174.1
H7C1S2
ENST00000236959.14 [P31939-1]
ENST00000444305.5
ENST00000427397.5