ASS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
epithelial cell	15 studies	37% ± 19%	Explore
endothelial cell	11 studies	26% ± 10%	Explore
secretory cell	10 studies	42% ± 11%	Explore
basal cell	9 studies	31% ± 13%	Explore
epithelial cell of proximal tubule	9 studies	57% ± 14%	Explore
endothelial cell of artery	9 studies	24% ± 9%	Explore
club cell	7 studies	40% ± 15%	Explore
respiratory goblet cell	7 studies	51% ± 22%	Explore
enterocyte	7 studies	39% ± 14%	Explore
goblet cell	7 studies	22% ± 4%	Explore
endothelial cell of vascular tree	6 studies	20% ± 3%	Explore
vein endothelial cell	5 studies	19% ± 5%	Explore
adipocyte	5 studies	24% ± 6%	Explore
hepatocyte	5 studies	73% ± 12%	Explore
fibroblast	4 studies	25% ± 3%	Explore
abnormal cell	4 studies	37% ± 22%	Explore
duct epithelial cell	3 studies	55% ± 24%	Explore
hillock cell	3 studies	37% ± 15%	Explore
mature NK T cell	3 studies	21% ± 5%	Explore
GABAergic neuron	3 studies	27% ± 7%	Explore
connective tissue cell	3 studies	24% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
kidney	4 studies	30% ± 17%	Explore
lung	3 studies	39% ± 11%	Explore
liver	3 studies	39% ± 6%	Explore
intestine	3 studies	24% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	60284.78	226 / 226	99%	673.64	400 / 406
ovary	99%	4093.30	179 / 180	99%	668.27	425 / 430
intestine	99%	7361.47	961 / 966	96%	453.58	504 / 527
thymus	100%	6767.10	652 / 653	90%	240.66	546 / 605
stomach	99%	3208.55	354 / 359	90%	314.04	258 / 286
uterus	100%	7026.14	170 / 170	84%	334.05	387 / 459
kidney	100%	34380.56	89 / 89	78%	131.17	704 / 901
lung	99%	4057.36	574 / 578	79%	156.11	908 / 1155
bladder	100%	6954.29	21 / 21	74%	267.49	375 / 504
pancreas	83%	1664.55	273 / 328	91%	205.62	162 / 178
esophagus	98%	3620.88	1420 / 1445	73%	149.72	134 / 183
breast	100%	12347.18	459 / 459	62%	118.14	696 / 1118
prostate	97%	4392.74	237 / 245	64%	75.33	319 / 502
adrenal gland	100%	10599.98	258 / 258	37%	146.53	86 / 230
skin	100%	5507.98	1803 / 1809	4%	4.38	17 / 472
adipose	100%	14376.35	1204 / 1204	0%	0	0 / 0
blood vessel	98%	4251.86	1314 / 1335	0%	0	0 / 0
muscle	95%	3058.87	762 / 803	0%	0	0 / 0
heart	94%	3018.10	807 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	261.54	40 / 45
brain	75%	2055.68	1969 / 2642	11%	10.30	77 / 705
spleen	60%	1225.65	144 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	21%	18.45	17 / 80
peripheral blood	4%	140.61	40 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0000052	Biological process	citrulline metabolic process
GO_0007584	Biological process	response to nutrient
GO_0032355	Biological process	response to estradiol
GO_0006953	Biological process	acute-phase response
GO_0071549	Biological process	cellular response to dexamethasone stimulus
GO_0007494	Biological process	midgut development
GO_0001822	Biological process	kidney development
GO_0001889	Biological process	liver development
GO_0060539	Biological process	diaphragm development
GO_0007623	Biological process	circadian rhythm
GO_0071346	Biological process	cellular response to type II interferon
GO_0060416	Biological process	response to growth hormone
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0071320	Biological process	cellular response to cAMP
GO_0000050	Biological process	urea cycle
GO_0071418	Biological process	cellular response to amine stimulus
GO_0071377	Biological process	cellular response to glucagon stimulus
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_0006531	Biological process	aspartate metabolic process
GO_0010043	Biological process	response to zinc ion
GO_0071230	Biological process	cellular response to amino acid stimulus
GO_0071242	Biological process	cellular response to ammonium ion
GO_0071400	Biological process	cellular response to oleic acid
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0010046	Biological process	response to mycotoxin
GO_0009410	Biological process	response to xenobiotic stimulus
GO_1903038	Biological process	negative regulation of leukocyte cell-cell adhesion
GO_0071499	Biological process	cellular response to laminar fluid shear stress
GO_0000053	Biological process	argininosuccinate metabolic process
GO_0006526	Biological process	arginine biosynthetic process
GO_0043204	Cellular component	perikaryon
GO_0070852	Cellular component	cell body fiber
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0042802	Molecular function	identical protein binding
GO_0016597	Molecular function	amino acid binding
GO_0015643	Molecular function	toxic substance binding
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0004055	Molecular function	argininosuccinate synthase activity

IV. Literature review

[source]

Gene name	ASS1
Protein name	Argininosuccinate synthase 1 isoform 2 Argininosuccinate synthase 1 isoform 3 Argininosuccinate synthase 1 Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)
Synonyms	ASS hCG_31245
Description	FUNCTION: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. .
Accessions	Q5T6L4 ENST00000422569.5 ENST00000443588.1 Q5T6L6 Q5T6L5 ENST00000372394.5 ENST00000352480.10 P00966 A0A0S2Z3D8 A0A0S2Z3B6 ENST00000372393.7 A0A0S2Z3F1

ASS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review