ASAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0061512Biological processprotein localization to cilium
GO_1903527Biological processpositive regulation of membrane tubulation
GO_0061000Biological processnegative regulation of dendritic spine development
GO_0045724Biological processpositive regulation of cilium assembly
GO_0043001Biological processGolgi to plasma membrane protein transport
GO_0099175Biological processregulation of postsynapse organization
GO_0098978Cellular componentglutamatergic synapse
GO_0043197Cellular componentdendritic spine
GO_0002102Cellular componentpodosome
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0045296Molecular functioncadherin binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0005096Molecular functionGTPase activator activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameASAP1
Protein nameAlternative protein ASAP1
ASAP1 protein
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (Development and differentiation enhancing factor 1, isoform CRA_b)
SynonymsDDEF1
PAG2
hCG_2009092
KIAA1249
DescriptionFUNCTION: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation . .

AccessionsENST00000524124.5
H0YBM4
A0A0A0MRE5
ENST00000520342.5
L8E8W2
E5RFD9
ENST00000521075.5
E5RHA9
ENST00000520927.5
ENST00000521426.5
ENST00000357668.2
ENST00000518721.6 [Q9ULH1-1]
ENST00000524299.1
E5RHD7
Q8WWA4
Q9ULH1
H0YBF7
ENST00000519483.5