ARMCX3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	26 studies	27% ± 10%	Explore
endothelial cell	22 studies	24% ± 10%	Explore
pericyte	18 studies	27% ± 11%	Explore
smooth muscle cell	17 studies	24% ± 7%	Explore
mast cell	15 studies	26% ± 7%	Explore
connective tissue cell	13 studies	27% ± 11%	Explore
plasma cell	11 studies	32% ± 10%	Explore
myofibroblast cell	9 studies	30% ± 11%	Explore
macrophage	9 studies	21% ± 5%	Explore
endothelial cell of lymphatic vessel	8 studies	23% ± 5%	Explore
endothelial cell of artery	8 studies	21% ± 6%	Explore
endothelial cell of vascular tree	8 studies	23% ± 12%	Explore
epithelial cell	7 studies	33% ± 22%	Explore
plasmacytoid dendritic cell	7 studies	24% ± 9%	Explore
capillary endothelial cell	6 studies	20% ± 5%	Explore
neuron	6 studies	37% ± 15%	Explore
conventional dendritic cell	5 studies	28% ± 11%	Explore
GABAergic neuron	5 studies	27% ± 12%	Explore
B cell	4 studies	21% ± 4%	Explore
natural killer cell	4 studies	22% ± 5%	Explore
plasmablast	4 studies	42% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	18% ± 1%	Explore
retinal ganglion cell	4 studies	58% ± 25%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	20% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	20% ± 2%	Explore
vein endothelial cell	4 studies	16% ± 1%	Explore
T cell	3 studies	22% ± 4%	Explore
pancreatic A cell	3 studies	35% ± 16%	Explore
CD4-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
podocyte	3 studies	55% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	17% ± 1%	Explore
neural crest cell	3 studies	17% ± 0%	Explore
IgA plasma cell	3 studies	16% ± 1%	Explore
myeloid cell	3 studies	23% ± 7%	Explore
platelet	3 studies	21% ± 7%	Explore
amacrine cell	3 studies	35% ± 7%	Explore
astrocyte	3 studies	25% ± 9%	Explore
retina horizontal cell	3 studies	24% ± 9%	Explore
monocyte	3 studies	26% ± 7%	Explore
ciliated cell	3 studies	34% ± 4%	Explore
Mueller cell	3 studies	26% ± 2%	Explore
CD8-positive, alpha-beta T cell	3 studies	20% ± 5%	Explore
dendritic cell	3 studies	45% ± 12%	Explore
innate lymphoid cell	3 studies	18% ± 1%	Explore
glutamatergic neuron	3 studies	40% ± 13%	Explore
oligodendrocyte precursor cell	3 studies	24% ± 6%	Explore
enteroendocrine cell	3 studies	30% ± 15%	Explore
goblet cell	3 studies	30% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 9%	Explore
interneuron	3 studies	34% ± 15%	Explore
basal cell	3 studies	31% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	26% ± 8%	Explore
eye	5 studies	19% ± 6%	Explore
brain	5 studies	29% ± 13%	Explore
intestine	4 studies	29% ± 13%	Explore
pancreas	3 studies	39% ± 14%	Explore
kidney	3 studies	17% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	4613.85	2642 / 2642	100%	96.63	705 / 705
prostate	100%	4380.36	245 / 245	100%	83.17	501 / 502
pancreas	100%	4653.42	328 / 328	99%	49.45	177 / 178
breast	100%	4485.24	459 / 459	99%	73.34	1104 / 1118
thymus	100%	5104.77	653 / 653	99%	273.31	596 / 605
kidney	100%	3840.19	89 / 89	98%	51.44	887 / 901
adrenal gland	100%	8233.66	258 / 258	98%	97.12	225 / 230
bladder	100%	4210.62	21 / 21	96%	39.03	482 / 504
lung	100%	4495.98	578 / 578	95%	40.84	1102 / 1155
intestine	100%	4024.21	965 / 966	92%	36.50	484 / 527
uterus	100%	5129.64	170 / 170	89%	41.20	407 / 459
ovary	100%	5490.57	180 / 180	88%	22.08	377 / 430
stomach	100%	3443.10	359 / 359	87%	34.09	250 / 286
skin	96%	2886.65	1730 / 1809	91%	51.21	429 / 472
esophagus	98%	3251.42	1420 / 1445	85%	27.73	155 / 183
liver	96%	1938.58	216 / 226	52%	18.08	213 / 406
adipose	100%	4500.50	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4819.24	1335 / 1335	0%	0	0 / 0
spleen	100%	5113.68	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	24.94	1 / 1
muscle	99%	2370.68	792 / 803	0%	0	0 / 0
heart	98%	3836.21	845 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	29.12	28 / 29
eye	0%	0	0 / 0	89%	34.27	71 / 80
tonsil	0%	0	0 / 0	78%	25.10	35 / 45
peripheral blood	67%	1543.74	619 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008104	Biological process	protein localization
GO_0007005	Biological process	mitochondrion organization
GO_0019896	Biological process	axonal transport of mitochondrion
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005829	Cellular component	cytosol
GO_1904115	Cellular component	axon cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARMCX3
Protein name	Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) Armadillo repeat containing X-linked 3
Synonyms	ALEX3 UNQ2517/PRO6007 BM-017
Description	FUNCTION: Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. .
Accessions	ENST00000341189.8 ENST00000491568.6 ENST00000471229.7 H3BV87 Q9UH62 H3BM63 ENST00000479298.5 ENST00000537169.1

ARMCX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review