AFG2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007420Biological processbrain development
GO_0042273Biological processribosomal large subunit biogenesis
GO_0007283Biological processspermatogenesis
GO_0030154Biological processcell differentiation
GO_0005819Cellular componentspindle
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_1990275Molecular functionpreribosome binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameAFG2A
Protein namevesicle-fusing ATPase (EC 3.6.4.6)
ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5)
SynonymsSPAF
SPATA5
DescriptionFUNCTION: ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles . Acts together with AFG2B, AIRIM and CINP . May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity). .

AccessionsA0A6Q8PGU6
ENST00000274008.5 [Q8NB90-1]
ENST00000675612.1
Q8NB90