ABHD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014909Biological processsmooth muscle cell migration
GO_0014912Biological processnegative regulation of smooth muscle cell migration
GO_0051793Biological processmedium-chain fatty acid catabolic process
GO_0048240Biological processsperm capacitation
GO_0007340Biological processacrosome reaction
GO_0051792Biological processmedium-chain fatty acid biosynthetic process
GO_0046464Biological processacylglycerol catabolic process
GO_0043401Biological processsteroid hormone receptor signaling pathway
GO_0009611Biological processresponse to wounding
GO_0032570Biological processresponse to progesterone
GO_0097524Cellular componentsperm plasma membrane
GO_0001669Cellular componentacrosomal vesicle
GO_0036126Cellular componentsperm flagellum
GO_0003707Molecular functionnuclear steroid receptor activity
GO_0004806Molecular functiontriglyceride lipase activity
GO_0042562Molecular functionhormone binding
GO_0033878Molecular functionhormone-sensitive lipase activity
GO_0008126Molecular functionacetylesterase activity
GO_0047372Molecular functionacylglycerol lipase activity

IV. Literature review

[source]
Gene nameABHD2
Protein nameMonoacylglycerol lipase ABHD2 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 2) (Acetylesterase) (EC 3.1.1.6) (Lung alpha/beta hydrolase 2) (Progesterone-sensitive lipase) (EC 3.1.1.79) (Protein PHPS1-2)
Abhydrolase domain containing 2, isoform CRA_a (Testicular tissue protein Li 6)
Abhydrolase domain containing 2, acylglycerol lipase
SynonymshCG_28637
LABH2
DescriptionFUNCTION: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane . Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) . Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester . Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation . May also play a role in smooth muscle cells migration (By similarity). .

AccessionsP08910
ENST00000569411.5
ENST00000565973.5
ENST00000565066.5
A0A024RC89
H3BUZ6
H3BN19
H3BMT2
ENST00000569550.5
ENST00000352732.10