ABCC1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	12 studies	28% ± 10%	Explore
mast cell	12 studies	34% ± 8%	Explore
regulatory T cell	8 studies	23% ± 9%	Explore
macrophage	8 studies	33% ± 13%	Explore
T cell	7 studies	22% ± 5%	Explore
fibroblast	6 studies	24% ± 6%	Explore
epithelial cell	5 studies	27% ± 8%	Explore
myeloid cell	5 studies	29% ± 8%	Explore
endothelial cell of lymphatic vessel	5 studies	26% ± 7%	Explore
type I pneumocyte	5 studies	36% ± 7%	Explore
basal cell	5 studies	26% ± 10%	Explore
GABAergic neuron	5 studies	33% ± 18%	Explore
CD4-positive, alpha-beta T cell	4 studies	28% ± 8%	Explore
adipocyte	4 studies	17% ± 2%	Explore
cardiac muscle cell	4 studies	18% ± 3%	Explore
dendritic cell	4 studies	21% ± 3%	Explore
club cell	4 studies	23% ± 5%	Explore
monocyte	4 studies	27% ± 8%	Explore
astrocyte	4 studies	35% ± 10%	Explore
interneuron	4 studies	38% ± 22%	Explore
microglial cell	3 studies	22% ± 5%	Explore
neuron	3 studies	24% ± 7%	Explore
ciliated cell	3 studies	18% ± 2%	Explore
retinal rod cell	3 studies	20% ± 1%	Explore
retinal pigment epithelial cell	3 studies	31% ± 19%	Explore
hematopoietic stem cell	3 studies	21% ± 4%	Explore
alveolar macrophage	3 studies	34% ± 9%	Explore
smooth muscle cell	3 studies	27% ± 6%	Explore
lymphocyte	3 studies	37% ± 10%	Explore
glutamatergic neuron	3 studies	42% ± 16%	Explore
oligodendrocyte	3 studies	24% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	24% ± 9%	Explore
eye	3 studies	22% ± 9%	Explore
lung	3 studies	23% ± 6%	Explore
adipose	3 studies	23% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	8741.88	1445 / 1445	100%	113.16	183 / 183
prostate	100%	5517.62	244 / 245	100%	44.85	502 / 502
intestine	100%	4469.78	966 / 966	99%	35.73	524 / 527
thymus	100%	7831.03	653 / 653	99%	30.43	601 / 605
lung	100%	5404.49	577 / 578	99%	82.29	1148 / 1155
uterus	100%	3437.18	170 / 170	99%	41.40	453 / 459
breast	100%	3110.27	459 / 459	99%	30.16	1103 / 1118
stomach	100%	4132.27	359 / 359	99%	36.57	282 / 286
bladder	100%	5253.33	21 / 21	98%	37.58	495 / 504
ovary	100%	2934.81	180 / 180	97%	27.23	418 / 430
kidney	99%	2170.92	88 / 89	95%	26.70	859 / 901
pancreas	96%	1691.03	314 / 328	98%	29.52	175 / 178
adrenal gland	100%	3778.95	258 / 258	93%	21.77	215 / 230
skin	100%	4496.72	1807 / 1809	93%	23.34	441 / 472
brain	48%	637.65	1276 / 2642	71%	9.30	499 / 705
adipose	100%	3394.72	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	32.88	29 / 29
spleen	100%	5316.75	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	51.13	45 / 45
ureter	0%	0	0 / 0	100%	29.99	1 / 1
muscle	100%	4040.61	801 / 803	0%	0	0 / 0
blood vessel	100%	4897.35	1329 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	93%	15.09	74 / 80
heart	92%	2280.26	796 / 861	0%	0	0 / 0
peripheral blood	80%	2774.32	745 / 929	0%	0	0 / 0
liver	10%	125.38	23 / 226	27%	6.32	111 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030148	Biological process	sphingolipid biosynthetic process
GO_0006805	Biological process	xenobiotic metabolic process
GO_0034775	Biological process	glutathione transmembrane transport
GO_0098656	Biological process	monoatomic anion transmembrane transport
GO_0055085	Biological process	transmembrane transport
GO_0150104	Biological process	transport across blood-brain barrier
GO_0070633	Biological process	transepithelial transport
GO_0015889	Biological process	cobalamin transport
GO_1990962	Biological process	xenobiotic transport across blood-brain barrier
GO_0099039	Biological process	sphingolipid translocation
GO_0042167	Biological process	heme catabolic process
GO_0070729	Biological process	cyclic nucleotide transport
GO_0140115	Biological process	export across plasma membrane
GO_1905039	Biological process	carboxylic acid transmembrane transport
GO_0042908	Biological process	xenobiotic transport
GO_0006691	Biological process	leukotriene metabolic process
GO_0034599	Biological process	cellular response to oxidative stress
GO_0045332	Biological process	phospholipid translocation
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0071716	Biological process	leukotriene transport
GO_1904646	Biological process	cellular response to amyloid-beta
GO_0060326	Biological process	cell chemotaxis
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0009925	Cellular component	basal plasma membrane
GO_0016328	Cellular component	lateral plasma membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0046943	Molecular function	carboxylic acid transmembrane transporter activity
GO_0015562	Molecular function	efflux transmembrane transporter activity
GO_0140359	Molecular function	ABC-type transporter activity
GO_0043225	Molecular function	ATPase-coupled inorganic anion transmembrane transporter activity
GO_0046624	Molecular function	sphingolipid transporter activity
GO_0008559	Molecular function	ABC-type xenobiotic transporter activity
GO_0015431	Molecular function	ABC-type glutathione S-conjugate transporter activity
GO_0042910	Molecular function	xenobiotic transmembrane transporter activity
GO_0015420	Molecular function	ABC-type vitamin B12 transporter activity
GO_0034634	Molecular function	glutathione transmembrane transporter activity
GO_0005524	Molecular function	ATP binding
GO_0042626	Molecular function	ATPase-coupled transmembrane transporter activity
GO_0034040	Molecular function	ATPase-coupled lipid transmembrane transporter activity
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	ABCC1
Protein name	ATP-binding cassette transporter variant ABCC1delta-ex25&26 ATP-binding cassette transporter variant ABCC1delta-ex25 Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) ATP-binding cassette transporter variant ABCC1delta-ex13&14 Multidrug resistance-associated protein 1 (EC 7.6.2.2) (EC 7.6.2.3) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (Leukotriene C(4) transporter) ATP-binding cassette transporter variant ABCC1delta-ex13
Synonyms	MRP MRP1
Description	FUNCTION: Mediates export of organic anions and drugs from the cytoplasm . Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics . Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export . Hydrolyzes ATP with low efficiency . Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation . Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export . Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway . .
Accessions	G0ZCM3 ENST00000399408.7 [P33527-9] ENST00000677164.1 A0A7I2V2E0 ENST00000572882.3 [P33527-2] G0ZCM6 ENST00000678422.1 ENST00000399410.8 [P33527-1] ENST00000622828.3 G0ZCM4 ENST00000621144.4 [P33527-1] I3L4X2 ENST00000572882 P33527 G0ZCM5 ENST00000399408 A0A0A0MS99 A0A7I2V4C6 ENST00000621659.2

ABCC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review