| Name | protein histidyl modification to diphthamide |
| ID | GO_0017183 |
| collection_id | Biological process |
| Exact synonym | peptidyl-diphthamide anabolism from peptidyl-histidine, peptidyl-diphthamide biosynthetic process from peptidyl-histidine, peptidyl-diphthamide formation from peptidyl-histidine, peptidyl-diphthamide synthesis from peptidyl-histidine |
| Description | The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria. |
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| Genes |