I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| CD4-positive, alpha-beta T cell | 4 studies | 20% ± 5% | |
| GABAergic neuron | 3 studies | 23% ± 5% | |
| glutamatergic neuron | 3 studies | 28% ± 7% | |
| astrocyte | 3 studies | 22% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| CD4-positive, alpha-beta T cell | 4 studies | 20% ± 5% | |
| GABAergic neuron | 3 studies | 23% ± 5% | |
| glutamatergic neuron | 3 studies | 28% ± 7% | |
| astrocyte | 3 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 654.42 | 226 / 226 | 100% | 17.08 | 406 / 406 |
| ovary | 100% | 1885.68 | 180 / 180 | 100% | 27.62 | 430 / 430 |
| prostate | 100% | 957.26 | 245 / 245 | 100% | 28.27 | 502 / 502 |
| breast | 100% | 926.26 | 459 / 459 | 100% | 27.05 | 1117 / 1118 |
| thymus | 100% | 906.04 | 653 / 653 | 100% | 29.18 | 604 / 605 |
| intestine | 100% | 862.95 | 966 / 966 | 100% | 22.41 | 526 / 527 |
| bladder | 100% | 1007.95 | 21 / 21 | 100% | 21.39 | 503 / 504 |
| pancreas | 100% | 1078.54 | 327 / 328 | 100% | 16.48 | 178 / 178 |
| brain | 100% | 676.05 | 2633 / 2642 | 100% | 29.72 | 705 / 705 |
| stomach | 100% | 739.85 | 359 / 359 | 100% | 19.73 | 285 / 286 |
| skin | 100% | 1214.62 | 1809 / 1809 | 100% | 25.18 | 470 / 472 |
| uterus | 100% | 1077.44 | 170 / 170 | 100% | 21.95 | 457 / 459 |
| esophagus | 100% | 827.43 | 1445 / 1445 | 99% | 16.10 | 182 / 183 |
| kidney | 100% | 744.01 | 89 / 89 | 99% | 18.25 | 895 / 901 |
| lung | 99% | 735.86 | 573 / 578 | 100% | 20.55 | 1155 / 1155 |
| adrenal gland | 100% | 1546.49 | 257 / 258 | 99% | 17.54 | 228 / 230 |
| adipose | 100% | 848.22 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 28.83 | 29 / 29 |
| muscle | 100% | 888.97 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 984.45 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 18.80 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.42 | 1 / 1 |
| blood vessel | 100% | 665.03 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 914.58 | 842 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 23.70 | 78 / 80 |
| peripheral blood | 85% | 742.08 | 786 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032259 | Biological process | methylation |
| GO_0017183 | Biological process | protein histidyl modification to diphthamide |
| GO_0005829 | Cellular component | cytosol |
| GO_0004164 | Molecular function | diphthine synthase activity |
| GO_0141133 | Molecular function | diphthine methyl ester synthase activity |
| Gene name | DPH5 |
| Protein name | Diphthine methyl ester synthase (EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase) DPH5 homolog (S. cerevisiae), isoform CRA_e (cDNA FLJ43496 fis, clone PEBLM2001465, highly similar to Probable diphthine synthase) DPH5 homolog (S. cerevisiae), isoform CRA_c (DPH5 protein) (Diphthine methyl ester synthase) |
| Synonyms | HSPC143 CGI-30 AD-018 NPD015 hCG_32849 |
| Description | FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. . |
| Accessions | Q9H2P9 ENST00000342173.11 [Q9H2P9-6] B3KWP1 ENST00000488176.1 [Q9H2P9-1] ENST00000427040 Q96DC6 ENST00000370109.8 [Q9H2P9-1] ENST00000427040.3 [Q9H2P9-1] |
