| Name | diphthine methyl ester synthase activity |
| ID | GO_0141133 |
| collection_id | Molecular function |
| Description | Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H+ + 4 S-adenosyl-L-homocysteine. |
| Comment | This activity is present in eukaryotes and is part of the biosynthetic pathway of diphthamide. Note that this is different from the archaeal enzyme, diphthine synthase activity ; GO:0004164 (EC:2.1.1.98), which performs only 3 methylations, producing diphthine. |
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| Genes |