DPH1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DPH1 at tissue level.

III. Associated gene sets

GO_0048144Biological processfibroblast proliferation
GO_0017183Biological processprotein histidyl modification to diphthamide
GO_0030054Cellular componentcell junction
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0090560Molecular function2-(3-amino-3-carboxypropyl)histidine synthase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameDPH1
Protein name2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)
Diphthamide biosynthesis 1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)
SynonymsDPH2L
OVCA1
DPH2L1
DescriptionFUNCTION: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 . DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Acts as a tumor suppressor . .

AccessionsENST00000570477.6 [Q9BZG8-2]
ENST00000674200.2 [Q9BZG8-1]
ENST00000575667.6
I3L3X9
V9GYS2
I3L1H5
ENST00000607788.2
A0A0A0MTR4
ENST00000571710.6
ENST00000571418.7
ENST00000570833.5
ENST00000263083.12 [Q9BZG8-4]
U3KQN3
ENST00000575162.2
V9GYC0
K7EQQ6
ENST00000263084.7
Q9BZG8