I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 27% ± 12% | |
| epithelial cell | 3 studies | 23% ± 5% | |
| GABAergic neuron | 3 studies | 27% ± 7% | |
| astrocyte | 3 studies | 18% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 27% ± 12% | |
| epithelial cell | 3 studies | 23% ± 5% | |
| GABAergic neuron | 3 studies | 27% ± 7% | |
| astrocyte | 3 studies | 18% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 25% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2112.23 | 1445 / 1445 | 100% | 12.22 | 183 / 183 |
| lung | 100% | 2140.97 | 578 / 578 | 100% | 13.99 | 1155 / 1155 |
| pancreas | 100% | 2495.63 | 328 / 328 | 100% | 14.28 | 178 / 178 |
| prostate | 100% | 3628.40 | 245 / 245 | 100% | 17.62 | 502 / 502 |
| uterus | 100% | 3335.04 | 170 / 170 | 100% | 19.68 | 459 / 459 |
| thymus | 100% | 3129.75 | 653 / 653 | 100% | 16.51 | 604 / 605 |
| intestine | 100% | 2617.05 | 966 / 966 | 100% | 16.47 | 526 / 527 |
| ovary | 100% | 3153.15 | 180 / 180 | 100% | 14.90 | 429 / 430 |
| skin | 100% | 2057.36 | 1808 / 1809 | 100% | 13.01 | 471 / 472 |
| stomach | 100% | 1951.40 | 359 / 359 | 100% | 13.52 | 285 / 286 |
| bladder | 100% | 2563.05 | 21 / 21 | 100% | 17.87 | 502 / 504 |
| adrenal gland | 100% | 2373.69 | 258 / 258 | 100% | 15.00 | 229 / 230 |
| brain | 100% | 1839.00 | 2630 / 2642 | 100% | 22.69 | 705 / 705 |
| breast | 100% | 2225.06 | 459 / 459 | 99% | 13.70 | 1111 / 1118 |
| kidney | 100% | 2109.57 | 89 / 89 | 97% | 9.51 | 878 / 901 |
| liver | 100% | 1323.22 | 226 / 226 | 95% | 8.20 | 385 / 406 |
| adipose | 100% | 1784.34 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 22.89 | 29 / 29 |
| spleen | 100% | 3368.80 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 16.42 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 11.61 | 1 / 1 |
| blood vessel | 100% | 1867.47 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 100% | 1390.95 | 859 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 10.74 | 79 / 80 |
| muscle | 99% | 995.60 | 792 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 84% | 941.42 | 780 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0017183 | Biological process | protein histidyl modification to diphthamide |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005515 | Molecular function | protein binding |
| GO_0061685 | Molecular function | diphthine methylesterase activity |
| Gene name | DPH7 |
| Protein name | Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis protein 7) (WD repeat-containing protein 85) |
| Synonyms | C9orf112 WDR85 |
| Description | FUNCTION: Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). . |
| Accessions | ENST00000277540.7 Q9BTV6 |
