DPH3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051099Biological processpositive regulation of binding
GO_0002926Biological processtRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO_0050709Biological processnegative regulation of protein secretion
GO_0017183Biological processprotein histidyl modification to diphthamide
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008198Molecular functionferrous iron binding
GO_0005515Molecular functionprotein binding
GO_0034986Molecular functioniron chaperone activity

IV. Literature review

[source]
Gene nameDPH3
Protein nameDiphthamide biosynthesis protein 3 (CSL-type zinc finger-containing protein 2) (DelGEF-interacting protein 1) (DelGIP1)
SynonymsZCSL2
DESR1
DescriptionFUNCTION: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). .

AccessionsENST00000488423.2 [Q96FX2-1]
Q96FX2
ENST00000383775.4 [Q96FX2-2]