DPH2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DPH2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DPH2 at tissue level.

III. Associated gene sets

GO_0017183Biological processprotein histidyl modification to diphthamide
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0090560Molecular function2-(3-amino-3-carboxypropyl)histidine synthase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameDPH2
Protein name2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
Diphthamide biosynthesis 2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)
SynonymshCG_25198
DPH2L2
DescriptionFUNCTION: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 . DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). .

FUNCTION: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. .

AccessionsE9PIY4
ENST00000524776.5
E9PLL2
E9PMH7
ENST00000492306.5
ENST00000532140.1
H0YCR5
ENST00000459879.1
ENST00000255108.8 [Q9BQC3-1]
ENST00000396758.6 [Q9BQC3-2]
ENST00000495421.1
ENST00000476260.1
E9PPU3
Q9BQC3
B3KRB8
E9PJH6