ZNF683 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZNF683 at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0010468Biological processregulation of gene expression
GO_0051136Biological processregulation of NK T cell differentiation
GO_0033082Biological processregulation of extrathymic T cell differentiation
GO_0032823Biological processregulation of natural killer cell differentiation
GO_0032826Biological processregulation of natural killer cell differentiation involved in immune response
GO_0045087Biological processinnate immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF683
Protein nameTissue-resident T-cell transcription regulator protein ZNF683 (Homolog of Blimp-1 in T-cell) (Hobit) (Zinc finger protein 683)
Zinc finger protein 683
Synonyms
DescriptionFUNCTION: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Also plays a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions. .; FUNCTION: [Isoform 1]: Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells. .; FUNCTION: [Isoform 2]: Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells. .

AccessionsQ5T145
ENST00000451801.5
A0A0A0MT21
X1WI31
ENST00000455900.5
ENST00000403843.5 [Q8IZ20-1]
ENST00000436292.5 [Q8IZ20-1]
ENST00000349618.8 [Q8IZ20-2]
Q5T142
ENST00000416125.1
ENST00000454975.1
ENST00000453132.5
X1WI32
A0A0A0MSJ7
ENST00000423508.5
Q8IZ20