Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 13 studies | 37% ± 19% | |
| macrophage | 9 studies | 36% ± 11% | |
| oligodendrocyte precursor cell | 9 studies | 31% ± 12% | |
| endothelial cell | 8 studies | 28% ± 13% | |
| microglial cell | 8 studies | 24% ± 8% | |
| dendritic cell | 6 studies | 23% ± 6% | |
| monocyte | 6 studies | 28% ± 9% | |
| interneuron | 5 studies | 32% ± 19% | |
| neuron | 5 studies | 28% ± 16% | |
| pericyte | 5 studies | 42% ± 21% | |
| GABAergic neuron | 5 studies | 37% ± 16% | |
| myeloid cell | 4 studies | 21% ± 7% | |
| epithelial cell | 4 studies | 44% ± 24% | |
| ciliated cell | 4 studies | 31% ± 7% | |
| retinal cone cell | 4 studies | 28% ± 15% | |
| retinal rod cell | 4 studies | 27% ± 12% | |
| basal cell | 4 studies | 46% ± 25% | |
| endothelial cell of lymphatic vessel | 4 studies | 38% ± 22% | |
| fibroblast | 4 studies | 40% ± 21% | |
| glutamatergic neuron | 4 studies | 35% ± 18% | |
| classical monocyte | 3 studies | 21% ± 1% | |
| smooth muscle cell | 3 studies | 40% ± 30% | |
| hepatocyte | 3 studies | 35% ± 18% | |
| connective tissue cell | 3 studies | 20% ± 3% | |
| ependymal cell | 3 studies | 34% ± 22% | |
| club cell | 3 studies | 25% ± 8% | |
| type II pneumocyte | 3 studies | 25% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2645.41 | 652 / 653 | 98% | 12.37 | 594 / 605 |
| esophagus | 100% | 2592.18 | 1445 / 1445 | 95% | 11.76 | 174 / 183 |
| lung | 100% | 2723.06 | 576 / 578 | 92% | 9.91 | 1066 / 1155 |
| pancreas | 97% | 1032.39 | 317 / 328 | 95% | 9.11 | 169 / 178 |
| kidney | 100% | 1608.87 | 89 / 89 | 90% | 7.83 | 807 / 901 |
| uterus | 100% | 11137.14 | 170 / 170 | 88% | 11.37 | 406 / 459 |
| intestine | 100% | 2623.97 | 966 / 966 | 88% | 5.93 | 465 / 527 |
| ovary | 100% | 8155.02 | 180 / 180 | 87% | 9.51 | 374 / 430 |
| breast | 100% | 2608.17 | 459 / 459 | 87% | 13.24 | 971 / 1118 |
| skin | 100% | 3317.10 | 1808 / 1809 | 85% | 11.99 | 403 / 472 |
| stomach | 100% | 1880.50 | 359 / 359 | 85% | 6.56 | 243 / 286 |
| adrenal gland | 100% | 2725.33 | 258 / 258 | 82% | 6.51 | 189 / 230 |
| prostate | 100% | 4013.47 | 245 / 245 | 81% | 7.06 | 406 / 502 |
| brain | 81% | 1070.49 | 2142 / 2642 | 99% | 14.10 | 699 / 705 |
| liver | 100% | 1231.17 | 226 / 226 | 79% | 5.42 | 321 / 406 |
| bladder | 100% | 3760.05 | 21 / 21 | 77% | 6.23 | 387 / 504 |
| spleen | 100% | 2533.29 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2148.30 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1772.14 | 800 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 3939.54 | 914 / 929 | 0% | 0 | 0 / 0 |
| heart | 93% | 1102.40 | 799 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 10.46 | 39 / 45 |
| blood vessel | 86% | 1207.40 | 1142 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 85% | 6.82 | 68 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 55% | 3.78 | 16 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050873 | Biological process | brown fat cell differentiation |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0060612 | Biological process | adipose tissue development |
| GO_0009409 | Biological process | response to cold |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0005634 | Cellular component | nucleus |
| GO_0000987 | Molecular function | cis-regulatory region sequence-specific DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | ZNF516 |
| Protein name | Zinc finger protein 516 ZNF516 protein |
| Synonyms | KIAA0222 |
| Description | FUNCTION: Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress . . |
| Accessions | H0YH41 ENST00000542818.1 F5H2K2 ENST00000443185.7 ENST00000617840.1 Q92618 Q2YDX2 A0A087WUJ4 ENST00000532857.1 |