ZNF516 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050873Biological processbrown fat cell differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0060612Biological processadipose tissue development
GO_0009409Biological processresponse to cold
GO_0006355Biological processregulation of DNA-templated transcription
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF516
Protein nameZinc finger protein 516
ZNF516 protein
SynonymsKIAA0222
DescriptionFUNCTION: Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress . .

AccessionsH0YH41
ENST00000542818.1
F5H2K2
ENST00000443185.7
ENST00000617840.1
Q92618
Q2YDX2
A0A087WUJ4
ENST00000532857.1