ZDHHC20 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016188Biological processsynaptic vesicle maturation
GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_0006612Biological processprotein targeting to membrane
GO_0044794Biological processpositive regulation by host of viral process
GO_0018345Biological processprotein palmitoylation
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0019705Molecular functionprotein-cysteine S-myristoyltransferase activity
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity
GO_0140439Molecular functionprotein-cysteine S-stearoyltransferase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameZDHHC20
Protein nameZinc finger DHHC-type palmitoyltransferase 20
Alternative protein ZDHHC20
Palmitoyltransferase (EC 2.3.1.225)
Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20)
Synonyms
DescriptionFUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates . Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation . Has a preference for acyl-CoA with C16 fatty acid chains . Can also utilize acyl-CoA with C14 and C18 fatty acid chains . .; FUNCTION: (Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. .

AccessionsENST00000400590.8 [Q5W0Z9-1]
A0A8V8TR49
ENST00000626464.2
ENST00000415724.2 [Q5W0Z9-1]
B4DRN8
ENST00000382466.7 [Q5W0Z9-3]
A0A0D9SEN4
L0R6T2
Q5W0Z9
ENST00000700725.1
ENST00000320220.13 [Q5W0Z9-4]
ENST00000542645.5