ZBED1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZBED1 at tissue level.

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_1990466Biological processprotein autosumoylation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0044828Biological processnegative regulation by host of viral genome replication
GO_0006355Biological processregulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0016605Cellular componentPML body
GO_0000785Cellular componentchromatin
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0019789Molecular functionSUMO transferase activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0061665Molecular functionSUMO ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZBED1
Protein nameE3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog)
Zinc finger BED-type containing 1
SynonymsDREF
hDREF
ALTE
KIAA0785
TRAMP
DescriptionFUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA . This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 . The resulting increased transcriptional activity drives cell proliferation . Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins . .; FUNCTION: (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection. .

AccessionsENST00000461691.6
ENST00000652001.1
ENST00000711173.1
ENST00000381223.9
ENST00000711171.1
ENST00000711172.1
ENST00000381218.8
ENST00000381222.8
C9JXP4
ENST00000711168.1
O96006
ENST00000711169.1