YTHDC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044829Biological processpositive regulation by host of viral genome replication
GO_0070555Biological processresponse to interleukin-1
GO_0034612Biological processresponse to tumor necrosis factor
GO_0051729Biological processgermline cell cycle switching, mitotic to meiotic cell cycle
GO_0048599Biological processoocyte development
GO_0051321Biological processmeiotic cell cycle
GO_0007286Biological processspermatid development
GO_0005622Cellular componentintracellular anatomical structure
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0035770Cellular componentribonucleoprotein granule
GO_0005783Cellular componentendoplasmic reticulum
GO_0070063Molecular functionRNA polymerase binding
GO_0004386Molecular functionhelicase activity
GO_0034458Molecular function3'-5' RNA helicase activity
GO_0008186Molecular functionATP-dependent activity, acting on RNA
GO_1990247Molecular functionN6-methyladenosine-containing RNA reader activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameYTHDC2
Protein nameRNA helicase (EC 3.6.4.13)
YTH domain containing 2
3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2)
Synonyms
DescriptionFUNCTION: 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells . Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability . Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease . Required for both spermatogenesis and oogenesis (By similarity). .

AccessionsENST00000514720.1
ENST00000503857.5
Q9H6S0
ENST00000515883.5
D6RF50
ENST00000161863.9
D6RA70
D6R9T8