Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 14 studies | 29% ± 12% | |
| glutamatergic neuron | 12 studies | 44% ± 26% | |
| astrocyte | 12 studies | 32% ± 14% | |
| microglial cell | 11 studies | 33% ± 11% | |
| oligodendrocyte precursor cell | 11 studies | 35% ± 16% | |
| oligodendrocyte | 11 studies | 29% ± 11% | |
| GABAergic neuron | 9 studies | 47% ± 25% | |
| macrophage | 8 studies | 34% ± 13% | |
| B cell | 7 studies | 19% ± 3% | |
| interneuron | 7 studies | 50% ± 23% | |
| fibroblast | 7 studies | 26% ± 10% | |
| adipocyte | 6 studies | 25% ± 6% | |
| neuron | 5 studies | 30% ± 13% | |
| epithelial cell | 5 studies | 33% ± 14% | |
| retina horizontal cell | 5 studies | 24% ± 12% | |
| dendritic cell | 5 studies | 20% ± 3% | |
| endothelial cell of lymphatic vessel | 5 studies | 30% ± 8% | |
| granule cell | 4 studies | 24% ± 5% | |
| lymphocyte | 4 studies | 23% ± 7% | |
| amacrine cell | 4 studies | 27% ± 10% | |
| pericyte | 4 studies | 26% ± 10% | |
| smooth muscle cell | 4 studies | 22% ± 3% | |
| GABAergic interneuron | 3 studies | 36% ± 2% | |
| retinal ganglion cell | 3 studies | 32% ± 20% | |
| cardiac muscle cell | 3 studies | 21% ± 0% | |
| ciliated cell | 3 studies | 19% ± 2% | |
| myeloid cell | 3 studies | 21% ± 3% | |
| retinal bipolar neuron | 3 studies | 24% ± 4% | |
| retinal cone cell | 3 studies | 29% ± 9% | |
| GABAergic amacrine cell | 3 studies | 28% ± 14% | |
| glycinergic amacrine cell | 3 studies | 27% ± 9% | |
| retinal rod cell | 3 studies | 33% ± 8% | |
| rod bipolar cell | 3 studies | 31% ± 16% | |
| hepatocyte | 3 studies | 29% ± 15% | |
| T cell | 3 studies | 17% ± 1% | |
| monocyte | 3 studies | 21% ± 4% | |
| basal cell | 3 studies | 32% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2985.64 | 1445 / 1445 | 100% | 13.03 | 183 / 183 |
| lung | 100% | 2996.12 | 578 / 578 | 100% | 9.35 | 1154 / 1155 |
| breast | 100% | 3391.37 | 459 / 459 | 99% | 16.54 | 1112 / 1118 |
| bladder | 100% | 3084.57 | 21 / 21 | 99% | 9.37 | 500 / 504 |
| thymus | 100% | 3954.87 | 653 / 653 | 99% | 9.77 | 599 / 605 |
| adrenal gland | 100% | 3425.28 | 258 / 258 | 99% | 11.34 | 227 / 230 |
| uterus | 100% | 3716.05 | 170 / 170 | 99% | 10.61 | 453 / 459 |
| prostate | 100% | 3141.91 | 245 / 245 | 99% | 12.08 | 495 / 502 |
| stomach | 100% | 2319.54 | 359 / 359 | 99% | 9.52 | 282 / 286 |
| pancreas | 100% | 1819.30 | 327 / 328 | 99% | 9.42 | 176 / 178 |
| kidney | 100% | 2128.76 | 89 / 89 | 98% | 12.17 | 887 / 901 |
| brain | 98% | 2306.62 | 2587 / 2642 | 100% | 11.26 | 705 / 705 |
| intestine | 100% | 3133.56 | 966 / 966 | 98% | 9.09 | 516 / 527 |
| liver | 100% | 1780.53 | 226 / 226 | 95% | 6.74 | 387 / 406 |
| skin | 100% | 3348.75 | 1809 / 1809 | 95% | 10.03 | 448 / 472 |
| ovary | 100% | 4235.37 | 180 / 180 | 94% | 5.01 | 403 / 430 |
| blood vessel | 100% | 3068.86 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 11.52 | 29 / 29 |
| spleen | 100% | 3652.77 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.48 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.12 | 1 / 1 |
| adipose | 100% | 3104.71 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2244.13 | 802 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 1821.09 | 840 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 78% | 5.31 | 62 / 80 |
| peripheral blood | 63% | 1233.15 | 582 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0044829 | Biological process | positive regulation by host of viral genome replication |
| GO_0070555 | Biological process | response to interleukin-1 |
| GO_0034612 | Biological process | response to tumor necrosis factor |
| GO_0051729 | Biological process | germline cell cycle switching, mitotic to meiotic cell cycle |
| GO_0048599 | Biological process | oocyte development |
| GO_0051321 | Biological process | meiotic cell cycle |
| GO_0007286 | Biological process | spermatid development |
| GO_0005622 | Cellular component | intracellular anatomical structure |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0035770 | Cellular component | ribonucleoprotein granule |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0070063 | Molecular function | RNA polymerase binding |
| GO_0004386 | Molecular function | helicase activity |
| GO_0034458 | Molecular function | 3'-5' RNA helicase activity |
| GO_0008186 | Molecular function | ATP-dependent activity, acting on RNA |
| GO_1990247 | Molecular function | N6-methyladenosine-containing RNA reader activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| Gene name | YTHDC2 |
| Protein name | RNA helicase (EC 3.6.4.13) YTH domain containing 2 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) |
| Synonyms | |
| Description | FUNCTION: 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells . Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability . Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease . Required for both spermatogenesis and oogenesis (By similarity). . |
| Accessions | ENST00000514720.1 ENST00000503857.5 Q9H6S0 ENST00000515883.5 D6RF50 ENST00000161863.9 D6RA70 D6R9T8 |