WDR26 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000151Cellular componentubiquitin ligase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0034657Cellular componentGID complex
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWDR26
Protein nameWD repeat-containing protein 26
WD repeat domain 26
WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2)
Alternative protein WDR26
SynonymsPRO0852
CDW2
MIP2
DescriptionFUNCTION: G-beta-like protein involved in cell signal transduction . Acts as a negative regulator in MAPK signaling pathway . Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes . Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 . Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation . Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration . Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria . Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity). .

AccessionsA0A7I2V3I7
ENST00000678307.1
L8EAE8
A0A7I2YQQ9
ENST00000414423.9
ENST00000704640.1
ENST00000486652.5
ENST00000678917.1 [Q9H7D7-1]
A0A994J579
ENST00000651911.2
ENST00000445239.1
A0A499FIZ0
Q9H7D7
ENST00000678879.1
C9JCS7
H0Y917
ENST00000704632.1
ENST00000480676.2
ENST00000678555.1
A0A7P0SXD0
A0A994J7J9
A0A7I2YQL3
H0Y9R3