Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| lung | 7 studies | 28% ± 6% | |
| intestine | 5 studies | 23% ± 11% | |
| kidney | 5 studies | 28% ± 5% | |
| pancreas | 4 studies | 55% ± 19% | |
| uterus | 4 studies | 30% ± 10% | |
| peripheral blood | 3 studies | 21% ± 0% | |
| placenta | 3 studies | 22% ± 4% | |
| breast | 3 studies | 18% ± 2% | |
| brain | 3 studies | 24% ± 3% | |
| liver | 3 studies | 33% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 100% | 3583.82 | 1809 / 1809 | 100% | 22.44 | 472 / 472 |
| liver | 100% | 7668.88 | 226 / 226 | 100% | 24.26 | 405 / 406 |
| adrenal gland | 100% | 3193.16 | 258 / 258 | 100% | 25.94 | 229 / 230 |
| uterus | 100% | 3477.54 | 170 / 170 | 100% | 16.89 | 457 / 459 |
| ovary | 100% | 3349.51 | 180 / 180 | 100% | 14.82 | 428 / 430 |
| thymus | 100% | 2581.19 | 653 / 653 | 99% | 12.85 | 600 / 605 |
| bladder | 100% | 3212.86 | 21 / 21 | 99% | 15.47 | 499 / 504 |
| prostate | 100% | 2551.99 | 245 / 245 | 99% | 14.69 | 497 / 502 |
| pancreas | 100% | 2528.37 | 328 / 328 | 99% | 17.61 | 176 / 178 |
| breast | 100% | 2763.25 | 459 / 459 | 99% | 19.11 | 1104 / 1118 |
| lung | 100% | 2437.40 | 577 / 578 | 99% | 12.78 | 1141 / 1155 |
| intestine | 100% | 2535.26 | 966 / 966 | 98% | 11.43 | 515 / 527 |
| kidney | 100% | 3442.82 | 89 / 89 | 97% | 24.51 | 877 / 901 |
| stomach | 100% | 2124.17 | 359 / 359 | 95% | 10.67 | 272 / 286 |
| esophagus | 100% | 2329.11 | 1444 / 1445 | 91% | 8.28 | 167 / 183 |
| brain | 98% | 1140.55 | 2598 / 2642 | 84% | 9.50 | 593 / 705 |
| adipose | 100% | 2941.84 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 4270.38 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 14.29 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 12.54 | 29 / 29 |
| spleen | 100% | 1850.23 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 33.05 | 1 / 1 |
| heart | 99% | 1812.74 | 855 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 9.04 | 42 / 45 |
| peripheral blood | 93% | 1405.37 | 863 / 929 | 0% | 0 | 0 / 0 |
| muscle | 67% | 474.28 | 538 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030193 | Biological process | regulation of blood coagulation |
| GO_0017187 | Biological process | peptidyl-glutamic acid carboxylation |
| GO_0014070 | Biological process | response to organic cyclic compound |
| GO_0060348 | Biological process | bone development |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0007596 | Biological process | blood coagulation |
| GO_0010243 | Biological process | response to organonitrogen compound |
| GO_0050820 | Biological process | positive regulation of coagulation |
| GO_0042373 | Biological process | vitamin K metabolic process |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0047057 | Molecular function | vitamin-K-epoxide reductase (warfarin-sensitive) activity |
| GO_0047058 | Molecular function | vitamin-K-epoxide reductase (warfarin-insensitive) activity |
| GO_0048038 | Molecular function | quinone binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | VKORC1 |
| Protein name | VKORC1 Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1) vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.17.4.4) Vitamin K epoxide reductase complex subunit 1 |
| Synonyms | VKOR MSTP576 MSTP134 UNQ308/PRO351 |
| Description | FUNCTION: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. . |
| Accessions | A0A0B5EFL6 E7BQW0 ENST00000394971.7 ENST00000300851.10 F8W9H0 A8MV79 A0A0S2Z6I4 ENST00000394975.3 [Q9BQB6-1] A0A0S2Z5X7 F2Z3Q2 ENST00000319788.11 [Q9BQB6-2] ENST00000498155.1 Q9BQB6 ENST00000420057.2 B5B596 ENST00000472468.1 ENST00000354895.4 [Q9BQB6-3] A0A0B5EEB2 E2DSP6 I3L1P9 H0YF24 |