USP36 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_1901524Biological processregulation of mitophagy
GO_0016242Biological processnegative regulation of macroautophagy
GO_0007000Biological processnucleolus organization
GO_2000232Biological processregulation of rRNA processing
GO_0006338Biological processchromatin remodeling
GO_0042981Biological processregulation of apoptotic process
GO_0050821Biological processprotein stabilization
GO_0006508Biological processproteolysis
GO_0016579Biological processprotein deubiquitination
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0031647Biological processregulation of protein stability
GO_0005730Cellular componentnucleolus
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0016740Molecular functiontransferase activity
GO_1990380Molecular functionK48-linked deubiquitinase activity
GO_0003723Molecular functionRNA binding
GO_0140936Molecular functionhistone H2B deubiquitinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUSP36
Protein nameUbiquitin carboxyl-terminal hydrolase 36
USP36 protein (Ubiquitin specific peptidase 36)
Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36)
Ubiquitin specific peptidase 36
Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
SynonymsKIAA1453
DescriptionFUNCTION: Deubiquitinase essential for the regulation of nucleolar structure and function . Required for cell and organism viability . Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability . Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) . Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex . In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm . Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions . Deubiquitinates SOD2, regulates SOD2 protein stability . Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins . Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability . Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing . Binds to pre-rRNAs . .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

AccessionsU3KQ92
K7ERP8
ENST00000586066.3
ENST00000588086.6
ENST00000588365.1
E9PEW0
ENST00000592275.5
A0A8I5QJW4
ENST00000591942.6
ENST00000542802.7
K7EJI3
K7EIT7
K7EKL7
K7EIH0
ENST00000589424.5
ENST00000449938
ENST00000449938.7
Q9P275
K7ELR5
K7EPT1
A0A075B784
ENST00000587379.1
K7EMM6
ENST00000592231.6
ENST00000588130.5
K7EKN3
ENST00000586896.2
ENST00000693020.1
ENST00000592231
K7ERC1
K7EQS0
ENST00000590546.6
ENST00000587010.5
ENST00000589225.5
ENST00000587783.5
ENST00000586531.5
K7ELT3
ENST00000591052.5
Q8IXW9
ENST00000312010.10