UPF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0006281Biological processDNA repair
GO_0032204Biological processregulation of telomere maintenance
GO_0006449Biological processregulation of translational termination
GO_0071044Biological processhistone mRNA catabolic process
GO_0071347Biological processcellular response to interleukin-1
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0006260Biological processDNA replication
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0006406Biological processmRNA export from nucleus
GO_0032201Biological processtelomere maintenance via semi-conservative replication
GO_0071222Biological processcellular response to lipopolysaccharide
GO_1905746Biological processpositive regulation of mRNA cis splicing, via spliceosome
GO_0044770Biological processcell cycle phase transition
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0061014Biological processpositive regulation of mRNA catabolic process
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0035145Cellular componentexon-exon junction complex
GO_0005654Cellular componentnucleoplasm
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0044530Cellular componentsupraspliceosomal complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0004386Molecular functionhelicase activity
GO_0003724Molecular functionRNA helicase activity
GO_0003682Molecular functionchromatin binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0036121Molecular functiondouble-stranded DNA helicase activity
GO_0042162Molecular functiontelomeric DNA binding
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameUPF1
Protein nameUPF1 RNA helicase and ATPase
UPF1
Regulator of nonsense transcripts 1 variant
Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1)
SynonymsKIAA0221
RENT1
hCG_37042
DescriptionFUNCTION: RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs . Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD . Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex . In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD . Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors . UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways . Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 . For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed . The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD . Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA . .

AccessionsA0A059XG67
A0A059XBJ1
A0A8A5YNF9
A0A059XBJ6
A0A8A5YP40
A0A059XG73
A0A994J4L7
A0A059XAM1
ENST00000599848.5 [Q92900-1]
ENST00000262803.10 [Q92900-2]
A0A059XAL2
A0A994J597
A0A8A5YPS5
A0A8A5YNG5
ENST00000704678.1
A0A059X4U2
Q92900
A0A059XAL6
A0A024R7L5
ENST00000704676.1
ENST00000704677.1
A0A994J773
A0A059XAJ5