UBE4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0009411Biological processresponse to UV
GO_0000209Biological processprotein polyubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0036503Biological processERAD pathway
GO_0008626Biological processgranzyme-mediated apoptotic signaling pathway
GO_0000151Cellular componentubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0034450Molecular functionubiquitin-ubiquitin ligase activity
GO_0019899Molecular functionenzyme binding

IV. Literature review

[source]
Gene nameUBE4B
Protein nameUbiquitination factor E4B
Ubiquitin conjugation factor E4 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4)
Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)
SynonymsUFD2
KIAA0684
HDNB1
DescriptionFUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation . .

FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. .

FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. .

AccessionsENST00000488228.1
ENST00000253251.12 [O95155-2]
K7EP75
B1AQ61
ENST00000343090.11 [O95155-1]
ENST00000470736.1
O95155
ENST00000377153.5
K7ERA7
ENST00000672724.1 [O95155-4]