Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 31% ± 15% | |
oligodendrocyte | 14 studies | 48% ± 17% | |
astrocyte | 13 studies | 34% ± 15% | |
oligodendrocyte precursor cell | 11 studies | 37% ± 17% | |
GABAergic neuron | 10 studies | 41% ± 22% | |
glutamatergic neuron | 10 studies | 47% ± 23% | |
microglial cell | 10 studies | 28% ± 10% | |
fibroblast | 10 studies | 27% ± 10% | |
macrophage | 9 studies | 33% ± 12% | |
adipocyte | 9 studies | 30% ± 7% | |
neuron | 7 studies | 38% ± 18% | |
interneuron | 6 studies | 49% ± 21% | |
epithelial cell | 6 studies | 34% ± 16% | |
endothelial cell of lymphatic vessel | 6 studies | 26% ± 9% | |
smooth muscle cell | 6 studies | 22% ± 4% | |
retinal ganglion cell | 5 studies | 31% ± 8% | |
cardiac muscle cell | 5 studies | 39% ± 9% | |
ciliated cell | 5 studies | 24% ± 7% | |
monocyte | 5 studies | 24% ± 4% | |
type I pneumocyte | 5 studies | 27% ± 7% | |
type II pneumocyte | 5 studies | 23% ± 6% | |
granule cell | 4 studies | 34% ± 7% | |
dendritic cell | 4 studies | 16% ± 1% | |
Mueller cell | 4 studies | 23% ± 6% | |
retinal rod cell | 4 studies | 30% ± 6% | |
club cell | 4 studies | 25% ± 8% | |
pericyte | 4 studies | 29% ± 9% | |
basal cell | 4 studies | 37% ± 22% | |
mast cell | 4 studies | 22% ± 6% | |
GABAergic interneuron | 3 studies | 34% ± 6% | |
plasma cell | 3 studies | 28% ± 7% | |
amacrine cell | 3 studies | 21% ± 4% | |
glycinergic amacrine cell | 3 studies | 17% ± 1% | |
retina horizontal cell | 3 studies | 21% ± 3% | |
retinal cone cell | 3 studies | 21% ± 4% | |
myeloid cell | 3 studies | 28% ± 5% | |
endothelial cell of vascular tree | 3 studies | 27% ± 14% | |
hepatocyte | 3 studies | 31% ± 10% | |
ependymal cell | 3 studies | 34% ± 20% | |
T cell | 3 studies | 19% ± 0% | |
alveolar macrophage | 3 studies | 34% ± 8% | |
lymphocyte | 3 studies | 26% ± 7% | |
goblet cell | 3 studies | 39% ± 27% | |
transit amplifying cell | 3 studies | 38% ± 28% | |
mucus secreting cell | 3 studies | 24% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5650.62 | 1445 / 1445 | 100% | 35.48 | 183 / 183 |
intestine | 100% | 5118.50 | 966 / 966 | 100% | 22.34 | 527 / 527 |
prostate | 100% | 3869.27 | 245 / 245 | 100% | 27.11 | 502 / 502 |
stomach | 100% | 4057.94 | 359 / 359 | 100% | 23.98 | 285 / 286 |
breast | 100% | 3427.20 | 459 / 459 | 100% | 26.29 | 1113 / 1118 |
ovary | 100% | 4710.88 | 180 / 180 | 100% | 28.19 | 428 / 430 |
thymus | 100% | 4353.57 | 653 / 653 | 100% | 27.09 | 602 / 605 |
bladder | 100% | 4456.95 | 21 / 21 | 99% | 21.75 | 501 / 504 |
skin | 100% | 5766.37 | 1809 / 1809 | 99% | 32.58 | 469 / 472 |
uterus | 100% | 5081.73 | 170 / 170 | 99% | 27.51 | 456 / 459 |
brain | 99% | 3857.41 | 2627 / 2642 | 100% | 22.93 | 704 / 705 |
lung | 99% | 3045.26 | 575 / 578 | 100% | 26.06 | 1151 / 1155 |
pancreas | 99% | 3716.55 | 326 / 328 | 98% | 17.49 | 175 / 178 |
kidney | 100% | 2521.49 | 89 / 89 | 97% | 16.88 | 870 / 901 |
adrenal gland | 100% | 5589.44 | 258 / 258 | 93% | 15.50 | 213 / 230 |
liver | 98% | 1847.15 | 221 / 226 | 87% | 11.50 | 355 / 406 |
adipose | 100% | 3513.21 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4481.54 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 47.32 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 16.46 | 29 / 29 |
muscle | 100% | 6333.49 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3224.28 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 31.93 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.53 | 1 / 1 |
heart | 97% | 3722.03 | 833 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 2306.11 | 855 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0009411 | Biological process | response to UV |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0036503 | Biological process | ERAD pathway |
GO_0008626 | Biological process | granzyme-mediated apoptotic signaling pathway |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0034450 | Molecular function | ubiquitin-ubiquitin ligase activity |
GO_0019899 | Molecular function | enzyme binding |
Gene name | UBE4B |
Protein name | Ubiquitination factor E4B Ubiquitin conjugation factor E4 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4) Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) |
Synonyms | UFD2 KIAA0684 HDNB1 |
Description | FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation . . FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. . FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. . |
Accessions | ENST00000488228.1 ENST00000253251.12 [O95155-2] K7EP75 B1AQ61 ENST00000343090.11 [O95155-1] ENST00000470736.1 O95155 ENST00000377153.5 K7ERA7 ENST00000672724.1 [O95155-4] |