UBE3C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0035519Biological processprotein K29-linked ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0000502Cellular componentproteasome complex
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBE3C
Protein nameUbiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Ubiquitin protein ligase E3C
SynonymsKIAA10
KIAA0010
DescriptionFUNCTION: E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains . Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome . Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins . Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation . Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages . Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome . Catalyzes ubiquitination and degradation of CAND2 . .

AccessionsENST00000348165.10 [Q15386-1]
H7C0Y1
ENST00000389103.4 [Q15386-3]
Q15386
ENST00000430750.1