Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 13 studies | 31% ± 14% | |
classical monocyte | 12 studies | 22% ± 7% | |
endothelial cell | 11 studies | 26% ± 11% | |
fibroblast | 8 studies | 22% ± 8% | |
basal cell | 7 studies | 24% ± 7% | |
macrophage | 7 studies | 22% ± 7% | |
epithelial cell | 7 studies | 38% ± 21% | |
neuron | 6 studies | 30% ± 14% | |
abnormal cell | 6 studies | 24% ± 10% | |
hematopoietic precursor cell | 5 studies | 23% ± 5% | |
monocyte | 5 studies | 24% ± 4% | |
non-classical monocyte | 5 studies | 28% ± 9% | |
pericyte | 5 studies | 19% ± 2% | |
oligodendrocyte precursor cell | 5 studies | 28% ± 11% | |
natural killer cell | 5 studies | 19% ± 2% | |
goblet cell | 5 studies | 24% ± 6% | |
plasmablast | 4 studies | 42% ± 17% | |
secretory cell | 4 studies | 19% ± 2% | |
squamous epithelial cell | 4 studies | 36% ± 21% | |
glutamatergic neuron | 4 studies | 31% ± 12% | |
astrocyte | 4 studies | 22% ± 5% | |
interneuron | 4 studies | 29% ± 11% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 18% ± 2% | |
myofibroblast cell | 4 studies | 17% ± 1% | |
smooth muscle cell | 4 studies | 18% ± 3% | |
B cell | 4 studies | 20% ± 6% | |
type I pneumocyte | 4 studies | 27% ± 5% | |
GABAergic neuron | 4 studies | 28% ± 12% | |
naive B cell | 4 studies | 18% ± 1% | |
plasmacytoid dendritic cell | 4 studies | 21% ± 5% | |
respiratory goblet cell | 3 studies | 32% ± 14% | |
pancreatic A cell | 3 studies | 49% ± 27% | |
conventional dendritic cell | 3 studies | 32% ± 8% | |
common myeloid progenitor | 3 studies | 22% ± 8% | |
myeloid cell | 3 studies | 32% ± 2% | |
pro-B cell | 3 studies | 25% ± 6% | |
type II pneumocyte | 3 studies | 23% ± 9% | |
dendritic cell | 3 studies | 35% ± 12% | |
enteroendocrine cell | 3 studies | 28% ± 9% | |
transit amplifying cell | 3 studies | 22% ± 5% | |
oligodendrocyte | 3 studies | 18% ± 3% | |
erythroblast | 3 studies | 28% ± 10% | |
T cell | 3 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 18606.33 | 1445 / 1445 | 100% | 248.57 | 183 / 183 |
ovary | 100% | 20265.83 | 180 / 180 | 100% | 344.39 | 430 / 430 |
prostate | 100% | 16622.41 | 245 / 245 | 100% | 216.11 | 502 / 502 |
skin | 100% | 20518.47 | 1809 / 1809 | 100% | 244.18 | 472 / 472 |
stomach | 100% | 12419.03 | 359 / 359 | 100% | 234.19 | 286 / 286 |
thymus | 100% | 26647.60 | 653 / 653 | 100% | 253.08 | 605 / 605 |
uterus | 100% | 21493.39 | 170 / 170 | 100% | 255.65 | 459 / 459 |
breast | 100% | 16667.68 | 459 / 459 | 100% | 256.69 | 1116 / 1118 |
intestine | 100% | 15872.95 | 966 / 966 | 100% | 231.95 | 526 / 527 |
bladder | 100% | 16275.29 | 21 / 21 | 100% | 214.15 | 503 / 504 |
lung | 100% | 17837.82 | 578 / 578 | 100% | 193.21 | 1152 / 1155 |
adrenal gland | 100% | 23951.15 | 258 / 258 | 100% | 193.53 | 229 / 230 |
brain | 99% | 13454.51 | 2628 / 2642 | 100% | 219.39 | 705 / 705 |
kidney | 100% | 17523.22 | 89 / 89 | 99% | 153.93 | 895 / 901 |
liver | 100% | 9153.74 | 225 / 226 | 99% | 111.07 | 402 / 406 |
pancreas | 99% | 7610.59 | 326 / 328 | 99% | 179.04 | 176 / 178 |
adipose | 100% | 15829.51 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 175.65 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 283.96 | 29 / 29 |
muscle | 100% | 19205.48 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 20089.66 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 199.59 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 114.83 | 1 / 1 |
blood vessel | 100% | 15823.08 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 16664.85 | 914 / 929 | 0% | 0 | 0 / 0 |
heart | 98% | 11515.92 | 845 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006974 | Biological process | DNA damage response |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0000792 | Cellular component | heterochromatin |
GO_0010008 | Cellular component | endosome membrane |
GO_0030057 | Cellular component | desmosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0030867 | Cellular component | rough endoplasmic reticulum membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004839 | Molecular function | ubiquitin activating enzyme activity |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | UBA1 |
Protein name | Ubiquitin like modifier activating enzyme 1 Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) |
Synonyms | UBE1 A1S9T |
Description | FUNCTION: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system . Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP . Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites . . |
Accessions | Q5JRR6 P22314 ENST00000451702.2 ENST00000442035.5 ENST00000377351.8 [P22314-1] ENST00000377269.3 Q5JRS2 ENST00000457753.5 ENST00000427561.5 ENST00000412206.5 Q5JRS1 ENST00000335972.11 [P22314-1] Q5JRR9 Q5JRS0 Q5JRS3 |