UBA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0000792Cellular componentheterochromatin
GO_0010008Cellular componentendosome membrane
GO_0030057Cellular componentdesmosome
GO_0070062Cellular componentextracellular exosome
GO_0030867Cellular componentrough endoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005765Cellular componentlysosomal membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004839Molecular functionubiquitin activating enzyme activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameUBA1
Protein nameUbiquitin like modifier activating enzyme 1
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A)
SynonymsUBE1
A1S9T
DescriptionFUNCTION: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system . Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP . Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites . .

AccessionsQ5JRR6
P22314
ENST00000451702.2
ENST00000442035.5
ENST00000377351.8 [P22314-1]
ENST00000377269.3
Q5JRS2
ENST00000457753.5
ENST00000427561.5
ENST00000412206.5
Q5JRS1
ENST00000335972.11 [P22314-1]
Q5JRR9
Q5JRS0
Q5JRS3