TSPAN5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0072659Biological processprotein localization to plasma membrane
GO_0051043Biological processregulation of membrane protein ectodomain proteolysis
GO_0051604Biological processprotein maturation
GO_0015629Cellular componentactin cytoskeleton
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0019899Molecular functionenzyme binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTSPAN5
Protein nameTetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)
Tetraspanin
Tetraspanin 5
SynonymsTM4SF9
DescriptionFUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates . Promotes ADAM10-mediated cleavage of CD44 . Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration . .

AccessionsD6RGZ7
ENST00000508798.5
D6RAR1
D6RBT5
ENST00000305798.8
ENST00000515440.5
ENST00000511800.5
B7Z317
ENST00000511651.5
ENST00000515287.5
ENST00000505184.5
D6R9N6
P62079
H0Y8W4