TSEN54 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TSEN54 at tissue level.

III. Associated gene sets

GO_0000379Biological processtRNA-type intron splice site recognition and cleavage
GO_0006397Biological processmRNA processing
GO_0006388Biological processtRNA splicing, via endonucleolytic cleavage and ligation
GO_0000214Cellular componenttRNA-intron endonuclease complex
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTSEN54
Protein nametRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)
tRNA splicing endonuclease subunit 54
SynonymsSEN54
DescriptionFUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. .

AccessionsA0A7P0Z4H0
ENST00000679928.1
ENST00000583173.5
A0A7P0TA59
ENST00000333213.11 [Q7Z6J9-1]
ENST00000680999.1
ENST00000681282.1
A0A7P0Z413
ENST00000545228.3
ENST00000583818.2
Q7Z6J9
ENST00000679429.1 [Q7Z6J9-2]
J9JIH8
J3KRC5
A0A7P0Z4K6
J3QLM6
ENST00000434205.8
E7EN92
ENST00000679782.1