Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 26 studies | 24% ± 7% | |
CD8-positive, alpha-beta T cell | 14 studies | 24% ± 7% | |
CD16-positive, CD56-dim natural killer cell, human | 13 studies | 30% ± 9% | |
mast cell | 12 studies | 25% ± 8% | |
mature NK T cell | 12 studies | 24% ± 8% | |
gamma-delta T cell | 12 studies | 25% ± 5% | |
CD16-negative, CD56-bright natural killer cell, human | 11 studies | 26% ± 7% | |
CD8-positive, alpha-beta memory T cell | 9 studies | 24% ± 5% | |
mucosal invariant T cell | 7 studies | 24% ± 4% | |
effector memory CD8-positive, alpha-beta T cell | 5 studies | 23% ± 6% | |
exhausted T cell | 4 studies | 21% ± 6% | |
epithelial cell | 4 studies | 23% ± 8% | |
CD4-positive, alpha-beta T cell | 4 studies | 19% ± 2% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 4 studies | 22% ± 7% | |
T cell | 3 studies | 17% ± 2% | |
effector CD8-positive, alpha-beta T cell | 3 studies | 21% ± 5% | |
group 3 innate lymphoid cell | 3 studies | 26% ± 4% | |
innate lymphoid cell | 3 studies | 24% ± 5% | |
plasmacytoid dendritic cell | 3 studies | 28% ± 4% |
Insufficient scRNA-seq data for expression of TSEN54 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
pancreas | 100% | 1689.48 | 328 / 328 | 100% | 35.07 | 178 / 178 |
uterus | 100% | 1319.75 | 170 / 170 | 100% | 51.00 | 459 / 459 |
esophagus | 100% | 1403.81 | 1444 / 1445 | 100% | 28.54 | 183 / 183 |
ovary | 100% | 1146.39 | 180 / 180 | 100% | 33.97 | 429 / 430 |
thymus | 100% | 1948.18 | 653 / 653 | 100% | 30.45 | 603 / 605 |
stomach | 100% | 1553.59 | 359 / 359 | 100% | 40.42 | 285 / 286 |
intestine | 100% | 1662.46 | 966 / 966 | 100% | 46.03 | 525 / 527 |
lung | 100% | 1788.59 | 578 / 578 | 100% | 38.61 | 1150 / 1155 |
prostate | 100% | 2123.10 | 245 / 245 | 99% | 31.96 | 499 / 502 |
skin | 100% | 1757.27 | 1809 / 1809 | 99% | 26.44 | 469 / 472 |
bladder | 100% | 1516.52 | 21 / 21 | 99% | 49.30 | 500 / 504 |
kidney | 100% | 2048.97 | 89 / 89 | 99% | 23.56 | 893 / 901 |
breast | 100% | 1342.12 | 459 / 459 | 99% | 43.01 | 1108 / 1118 |
brain | 99% | 1355.97 | 2613 / 2642 | 99% | 21.18 | 701 / 705 |
liver | 100% | 954.53 | 226 / 226 | 98% | 26.52 | 396 / 406 |
adrenal gland | 100% | 1405.77 | 258 / 258 | 93% | 15.67 | 213 / 230 |
lymph node | 0% | 0 | 0 / 0 | 100% | 35.31 | 29 / 29 |
spleen | 100% | 2520.44 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 37.43 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 48.21 | 1 / 1 |
adipose | 100% | 996.17 | 1200 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 817.38 | 1324 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 15.29 | 77 / 80 |
heart | 93% | 520.69 | 799 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 1536.65 | 851 / 929 | 0% | 0 | 0 / 0 |
muscle | 89% | 506.96 | 711 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0000379 | Biological process | tRNA-type intron splice site recognition and cleavage |
GO_0006397 | Biological process | mRNA processing |
GO_0006388 | Biological process | tRNA splicing, via endonucleolytic cleavage and ligation |
GO_0000214 | Cellular component | tRNA-intron endonuclease complex |
GO_0005730 | Cellular component | nucleolus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005515 | Molecular function | protein binding |
Gene name | TSEN54 |
Protein name | tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) tRNA splicing endonuclease subunit 54 |
Synonyms | SEN54 |
Description | FUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. . |
Accessions | A0A7P0Z4H0 ENST00000679928.1 ENST00000583173.5 A0A7P0TA59 ENST00000333213.11 [Q7Z6J9-1] ENST00000680999.1 ENST00000681282.1 A0A7P0Z413 ENST00000545228.3 ENST00000583818.2 Q7Z6J9 ENST00000679429.1 [Q7Z6J9-2] J9JIH8 J3KRC5 A0A7P0Z4K6 J3QLM6 ENST00000434205.8 E7EN92 ENST00000679782.1 |