TRMT10C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_1990180Biological processmitochondrial tRNA 3'-end processing
GO_0070901Biological processmitochondrial tRNA methylation
GO_0000964Biological processmitochondrial RNA 5'-end processing
GO_0090646Biological processmitochondrial tRNA processing
GO_0097745Biological processmitochondrial tRNA 5'-end processing
GO_0070131Biological processpositive regulation of mitochondrial translation
GO_0042645Cellular componentmitochondrial nucleoid
GO_0005739Cellular componentmitochondrion
GO_0043527Cellular componenttRNA methyltransferase complex
GO_0005654Cellular componentnucleoplasm
GO_0030678Cellular componentmitochondrial ribonuclease P complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005634Cellular componentnucleus
GO_0160106Molecular functiontRNA (adenine(9)-N1)-methyltransferase activity
GO_0042802Molecular functionidentical protein binding
GO_0052905Molecular functiontRNA (guanosine(9)-N1)-methyltransferase activity
GO_0003723Molecular functionRNA binding
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRMT10C
Protein nametRNA (guanine(9)-N(1))-methyltransferase (EC 2.1.1.221)
tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221)
SynonymsMRPP1
RG9MTD1
DescriptionFUNCTION: Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation . Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends . Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity . The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit . The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme . In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA . Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. .

AccessionsENST00000495642.1
ENST00000309922.7
C9JVB6
Q7L0Y3