TRIM5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM5 at tissue level.

III. Associated gene sets

GO_0000209Biological processprotein polyubiquitination
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045087Biological processinnate immune response
GO_0051607Biological processdefense response to virus
GO_0032880Biological processregulation of protein localization
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0046597Biological processnegative regulation of viral entry into host cell
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0010508Biological processpositive regulation of autophagy
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0002218Biological processactivation of innate immune response
GO_0006914Biological processautophagy
GO_0031664Biological processregulation of lipopolysaccharide-mediated signaling pathway
GO_0044790Biological processsuppression of viral release by host
GO_0046596Biological processregulation of viral entry into host cell
GO_1990462Cellular componentomegasome
GO_0005654Cellular componentnucleoplasm
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0038187Molecular functionpattern recognition receptor activity
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM5
Protein nameTripartite motif-containing protein 5 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM5)
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
TRIM5
TRIM5 protein
Tripartite motif containing 5
Trim5alpha
SynonymsTRIM5alpha
RNF88
DescriptionFUNCTION: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) . Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 . Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction . .

AccessionsD8L1Z7
ENST00000380034.8 [Q9C035-1]
C9JWN8
L7REZ6
ENST00000419850.1
Q9C035
ENST00000396847.7 [Q9C035-3]
H7C134
A0A804HHS7
D8L200
D8L1Z9
ENST00000682968.1
ENST00000438025.5
ENST00000380027.5 [Q9C035-4]
E7EQQ5
ENST00000433961.5 [Q9C035-5]
L7RET5
D8L1Z8
ENST00000412903.1
D8L203
Q05CU3
D8L201
ENST00000684655.1 [Q9C035-1]
B1Q3L0
D8L202