TOPORS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0000209Biological processprotein polyubiquitination
GO_0051443Biological processpositive regulation of ubiquitin-protein transferase activity
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0051457Biological processmaintenance of protein location in nucleus
GO_0006351Biological processDNA-templated transcription
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0034504Biological processprotein localization to nucleus
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0006513Biological processprotein monoubiquitination
GO_0042127Biological processregulation of cell population proliferation
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000151Cellular componentubiquitin ligase complex
GO_0030496Cellular componentmidbody
GO_0032391Cellular componentphotoreceptor connecting cilium
GO_0000922Cellular componentspindle pole
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005814Cellular componentcentriole
GO_0000930Cellular componentgamma-tubulin complex
GO_0016605Cellular componentPML body
GO_0036064Cellular componentciliary basal body
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019789Molecular functionSUMO transferase activity
GO_0044547Molecular functionDNA topoisomerase binding
GO_0046872Molecular functionmetal ion binding
GO_0003823Molecular functionantigen binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTOPORS
Protein nameE3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)
SynonymsLUN
TP53BPL
DescriptionFUNCTION: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. .

AccessionsQ9NS56
ENST00000379858.1 [Q9NS56-2]
ENST00000360538.7 [Q9NS56-1]