TOP3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006310Biological processDNA recombination
GO_0051321Biological processmeiotic cell cycle
GO_0006281Biological processDNA repair
GO_0071139Biological processresolution of DNA recombination intermediates
GO_0032042Biological processmitochondrial DNA metabolic process
GO_0006265Biological processDNA topological change
GO_0051304Biological processchromosome separation
GO_0016605Cellular componentPML body
GO_0005654Cellular componentnucleoplasm
GO_0031422Cellular componentRecQ family helicase-topoisomerase III complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003917Molecular functionDNA topoisomerase type I (single strand cut, ATP-independent) activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTOP3A
Protein nameDNA topoisomerase 3-alpha (DNA topoisomerase III alpha)
DNA topoisomerase (EC 5.6.2.1)
DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)
SynonymsTOP3
DescriptionFUNCTION: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity . It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2 . .

FUNCTION: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. .

FUNCTION: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. .

FUNCTION: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. .

FUNCTION: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. .

FUNCTION: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. .

AccessionsJ3QR18
ENST00000493648.1
ENST00000640917.1
ENST00000582981.5
ENST00000639065.1 [Q13472-2]
ENST00000640882.1
J3QS25
ENST00000489131.1
J3KS96
ENST00000585031.2
ENST00000640743.2 [Q13472-1]
ENST00000581536.5
K7EL07
ENST00000638894.1 [Q13472-1]
ENST00000584582.5
ENST00000321105.10 [Q13472-1]
ENST00000639180.1
ENST00000580095.5 [Q13472-2]
ENST00000640740.1
ENST00000640167.1
ENST00000461127.5
Q13472
K7EMT6
ENST00000582122.1
ENST00000639383.1
ENST00000639826.1
K7EJ41
J3KRR9
ENST00000542570.5 [Q13472-1]
ENST00000640624.1
K7ELI7