TOP2A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TOP2A at tissue level.

III. Associated gene sets

GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0007059Biological processchromosome segregation
GO_0006974Biological processDNA damage response
GO_0007143Biological processfemale meiotic nuclear division
GO_0030263Biological processapoptotic chromosome condensation
GO_0042752Biological processregulation of circadian rhythm
GO_1905463Biological processnegative regulation of DNA duplex unwinding
GO_0006265Biological processDNA topological change
GO_0000712Biological processresolution of meiotic recombination intermediates
GO_0040016Biological processembryonic cleavage
GO_0000819Biological processsister chromatid segregation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0006266Biological processDNA ligation
GO_0048511Biological processrhythmic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0045870Biological processpositive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0000775Cellular componentchromosome, centromeric region
GO_0005730Cellular componentnucleolus
GO_0000228Cellular componentnuclear chromosome
GO_0009330Cellular componentDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005814Cellular componentcentriole
GO_0005737Cellular componentcytoplasm
GO_0000793Cellular componentcondensed chromosome
GO_0001673Cellular componentmale germ cell nucleus
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0008301Molecular functionDNA binding, bending
GO_0003682Molecular functionchromatin binding
GO_0003918Molecular functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameTOP2A
Protein nameDNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
DNA topoisomerase 2 (EC 5.6.2.2)
DNA topoisomerase II alpha
SynonymsTOP2
DescriptionFUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand . May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). .

FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. .

AccessionsENST00000581055.1
ENST00000423485.6 [P11388-1]
J3KTB7
A0A4D6UXC9
J3QR57
ENST00000577541.1
P11388