TNK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006897Biological processendocytosis
GO_2000369Biological processregulation of clathrin-dependent endocytosis
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0016310Biological processphosphorylation
GO_0006468Biological processprotein phosphorylation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0030136Cellular componentclathrin-coated vesicle
GO_0070436Cellular componentGrb2-EGFR complex
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005905Cellular componentclathrin-coated pit
GO_0097268Cellular componentcytoophidium
GO_0005768Cellular componentendosome
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005634Cellular componentnucleus
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005095Molecular functionGTPase inhibitor activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0050699Molecular functionWW domain binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNK2
Protein nameActivated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
non-specific protein-tyrosine kinase (EC 2.7.10.2)
Tyrosine kinase non receptor 2
SynonymsACK1
hCG_2004203
DescriptionFUNCTION: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP . .

AccessionsENST00000673420.1
ENST00000381916.7
A0A5F9ZGY5
ENST00000671734.1
A0A5F9ZGX5
ENST00000672024.1
A0A5F9ZI29
A0A5F9ZHX6
ENST00000672098.1
ENST00000673038.1
ENST00000333602.14 [Q07912-1]
ENST00000672887.2
ENST00000673374.1
A0A5F9ZHQ1
C9J1X3
ENST00000672548.1
A0A5F9ZHP9
ENST00000671767.1
ENST00000428187.7
ENST00000673559.1
ENST00000672145.1
A0A5F9ZHB0
ENST00000673443.1
A0A5F9ZH66
ENST00000672542.1
A0A5F9ZHI7
A0A5F9ZHJ2
A0A499FJ16
A0A5F9ZHP4
ENST00000671753.1 [Q07912-3]
A0A5F9ZHC7
A0A5F9ZI44
ENST00000672669.1
ENST00000678220.1
ENST00000671880.1
A0A5F9ZHL4
ENST00000439230.6 [Q07912-2]
ENST00000672886.1
Q07912
A0A5F9ZHD0
A0A5F9ZHK8
ENST00000672623.1
A0A5F9ZH01