TMT1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042476Biological processodontogenesis
GO_0032259Biological processmethylation
GO_0180035Biological processlncRNA processing
GO_0001649Biological processosteoblast differentiation
GO_1904724Cellular componenttertiary granule lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0005811Cellular componentlipid droplet
GO_0016020Cellular componentmembrane
GO_0008173Molecular functionRNA methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0018708Molecular functionthiol S-methyltransferase activity
GO_0001734Molecular functionmRNA m(6)A methyltransferase activity
GO_0008168Molecular functionmethyltransferase activity

IV. Literature review

[source]
Gene nameTMT1A
Protein nameThiol S-methyltransferase TMT1A (EC 2.1.1.9) (Methyltransferase-like protein 7A) (N6-adenosine-methyltransferase TMT1A) (EC 2.1.1.348) (Protein AAM-B) (Thiol methyltransferase 1A)
Methyltransferase like 7A
SynonymsPRO0066
UNQ1902/PRO4348
METTL7A
DescriptionFUNCTION: Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes . Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface . Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival . Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles . .; FUNCTION: (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation. .

AccessionsF8VQX6
ENST00000548553.1
ENST00000332160.5
ENST00000550502.1
H0YI09
ENST00000550097.1
Q9H8H3
ENST00000547104.1