TMEM70 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051259Biological processprotein complex oligomerization
GO_0051260Biological processprotein homooligomerization
GO_0033615Biological processmitochondrial proton-transporting ATP synthase complex assembly
GO_0031966Cellular componentmitochondrial membrane
GO_0005654Cellular componentnucleoplasm
GO_0030061Cellular componentmitochondrial crista
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0140260Molecular functionmitochondrial proton-transporting ATP synthase complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMEM70
Protein nameTransmembrane protein 70
Transmembrane protein 70, mitochondrial
Alternative protein TMEM70
Synonyms
DescriptionFUNCTION: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction . Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis . In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies . .

AccessionsENST00000416961.6
ENST00000517439.1 [Q9BUB7-3]
D4PHA6
L0R5D5
Q9BUB7
ENST00000312184.6 [Q9BUB7-1]