TMEM106B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_1905146Biological processlysosomal protein catabolic process
GO_1905671Biological processregulation of lysosome organization
GO_0070050Biological processneuron cellular homeostasis
GO_1900006Biological processpositive regulation of dendrite development
GO_0032418Biological processlysosome localization
GO_0007042Biological processlysosomal lumen acidification
GO_0048813Biological processdendrite morphogenesis
GO_0007041Biological processlysosomal transport
GO_0005764Cellular componentlysosome
GO_0005768Cellular componentendosome
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameTMEM106B
Protein nameTransmembrane protein 106B
SynonymshCG_1639909
DescriptionFUNCTION: In neurons, involved in the transport of late endosomes/lysosomes . May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking . May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress . Required for proper lysosomal acidification (By similarity). .; FUNCTION: (Microbial infection) Plays a role in human coronavirus SARS-CoV-2 infection, but not in common cold coronaviruses HCoV-229E and HCoV-OC43 infections. Involved in ACE2-independent SARS-CoV-2 cell entry. Required for post-endocytic stage of virus entry, facilitates spike-mediated membrane fusion. Virus attachment and endocytosis can also be mediated by other cell surface receptors. .

AccessionsENST00000704455.1
A0A994J4F8
A0A994J4C4
ENST00000420833.5
A0A994J4M3
ENST00000444443.6
C9JZ87
ENST00000704457.1
ENST00000704348.1
ENST00000442107.1
Q9NUM4
A0A994J7D5
ENST00000704417.1
A0A994J517
ENST00000704349.1
ENST00000704416.1
C9J998
ENST00000704347.1
F2Z3N7
ENST00000396668.8
Q8N353
ENST00000396667.7