Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 25% ± 5% | |
fibroblast | 10 studies | 24% ± 9% | |
glutamatergic neuron | 9 studies | 36% ± 22% | |
epithelial cell | 9 studies | 32% ± 16% | |
oligodendrocyte | 9 studies | 25% ± 8% | |
astrocyte | 8 studies | 25% ± 8% | |
GABAergic neuron | 7 studies | 40% ± 19% | |
oligodendrocyte precursor cell | 7 studies | 31% ± 14% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 6 studies | 19% ± 3% | |
neuron | 6 studies | 29% ± 10% | |
smooth muscle cell | 6 studies | 21% ± 4% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 5 studies | 18% ± 2% | |
myofibroblast cell | 5 studies | 18% ± 3% | |
CD4-positive, alpha-beta T cell | 4 studies | 24% ± 7% | |
basal cell | 4 studies | 33% ± 9% | |
ciliated cell | 4 studies | 31% ± 7% | |
amacrine cell | 4 studies | 27% ± 10% | |
Mueller cell | 4 studies | 27% ± 8% | |
interneuron | 4 studies | 48% ± 20% | |
secretory cell | 3 studies | 22% ± 8% | |
squamous epithelial cell | 3 studies | 50% ± 20% | |
pancreatic D cell | 3 studies | 32% ± 22% | |
type B pancreatic cell | 3 studies | 38% ± 22% | |
pericyte | 3 studies | 20% ± 2% | |
retina horizontal cell | 3 studies | 24% ± 0% | |
retinal rod cell | 3 studies | 20% ± 3% | |
pancreatic A cell | 3 studies | 34% ± 16% | |
pancreatic ductal cell | 3 studies | 47% ± 26% | |
goblet cell | 3 studies | 18% ± 1% | |
intestinal crypt stem cell | 3 studies | 19% ± 2% | |
connective tissue cell | 3 studies | 27% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2429.61 | 1445 / 1445 | 100% | 27.00 | 183 / 183 |
brain | 100% | 2859.56 | 2639 / 2642 | 100% | 32.16 | 703 / 705 |
adrenal gland | 100% | 5667.52 | 258 / 258 | 100% | 20.09 | 229 / 230 |
ovary | 100% | 2949.39 | 180 / 180 | 100% | 17.85 | 428 / 430 |
lung | 99% | 2129.91 | 575 / 578 | 100% | 25.94 | 1154 / 1155 |
breast | 100% | 2555.63 | 459 / 459 | 99% | 23.71 | 1106 / 1118 |
thymus | 100% | 3222.75 | 653 / 653 | 99% | 22.44 | 596 / 605 |
prostate | 100% | 2798.26 | 245 / 245 | 98% | 19.56 | 494 / 502 |
kidney | 100% | 2305.54 | 89 / 89 | 98% | 22.76 | 885 / 901 |
pancreas | 98% | 1502.33 | 323 / 328 | 99% | 16.29 | 176 / 178 |
stomach | 100% | 1936.70 | 359 / 359 | 97% | 21.52 | 278 / 286 |
intestine | 100% | 3059.98 | 966 / 966 | 97% | 18.41 | 512 / 527 |
bladder | 100% | 2824.05 | 21 / 21 | 97% | 14.87 | 489 / 504 |
liver | 100% | 1998.22 | 226 / 226 | 96% | 12.49 | 388 / 406 |
uterus | 100% | 3905.02 | 170 / 170 | 95% | 12.38 | 435 / 459 |
skin | 100% | 2641.76 | 1805 / 1809 | 89% | 15.58 | 420 / 472 |
blood vessel | 100% | 3051.83 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1783.95 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.05 | 1 / 1 |
adipose | 100% | 2582.85 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 2446.38 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 2033.41 | 841 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 10.27 | 42 / 45 |
lymph node | 0% | 0 | 0 / 0 | 66% | 5.11 | 19 / 29 |
peripheral blood | 56% | 576.60 | 524 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 49% | 4.16 | 39 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007040 | Biological process | lysosome organization |
GO_1905146 | Biological process | lysosomal protein catabolic process |
GO_1905671 | Biological process | regulation of lysosome organization |
GO_0070050 | Biological process | neuron cellular homeostasis |
GO_1900006 | Biological process | positive regulation of dendrite development |
GO_0032418 | Biological process | lysosome localization |
GO_0007042 | Biological process | lysosomal lumen acidification |
GO_0048813 | Biological process | dendrite morphogenesis |
GO_0007041 | Biological process | lysosomal transport |
GO_0005764 | Cellular component | lysosome |
GO_0005768 | Cellular component | endosome |
GO_0031902 | Cellular component | late endosome membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0051117 | Molecular function | ATPase binding |
GO_0005515 | Molecular function | protein binding |
GO_0003674 | Molecular function | molecular_function |
Gene name | TMEM106B |
Protein name | Transmembrane protein 106B |
Synonyms | hCG_1639909 |
Description | FUNCTION: In neurons, involved in the transport of late endosomes/lysosomes . May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking . May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress . Required for proper lysosomal acidification (By similarity). .; FUNCTION: (Microbial infection) Plays a role in human coronavirus SARS-CoV-2 infection, but not in common cold coronaviruses HCoV-229E and HCoV-OC43 infections. Involved in ACE2-independent SARS-CoV-2 cell entry. Required for post-endocytic stage of virus entry, facilitates spike-mediated membrane fusion. Virus attachment and endocytosis can also be mediated by other cell surface receptors. . |
Accessions | ENST00000704455.1 A0A994J4F8 A0A994J4C4 ENST00000420833.5 A0A994J4M3 ENST00000444443.6 C9JZ87 ENST00000704457.1 ENST00000704348.1 ENST00000442107.1 Q9NUM4 A0A994J7D5 ENST00000704417.1 A0A994J517 ENST00000704349.1 ENST00000704416.1 C9J998 ENST00000704347.1 F2Z3N7 ENST00000396668.8 Q8N353 ENST00000396667.7 |