TMEM106A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TMEM106A at tissue level.

III. Associated gene sets

GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_1904407Biological processpositive regulation of nitric oxide metabolic process
GO_0035781Biological processCD86 biosynthetic process
GO_0042116Biological processmacrophage activation
GO_0045348Biological processpositive regulation of MHC class II biosynthetic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0008150Biological processbiological_process
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045087Biological processinnate immune response
GO_0035780Biological processCD80 biosynthetic process
GO_0005886Cellular componentplasma membrane
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameTMEM106A
Protein nameTransmembrane protein 106A
Synonyms
DescriptionFUNCTION: Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration . .

AccessionsENST00000588659.5 [Q96A25-1]
ENST00000536052.5
ENST00000612339.4 [Q96A25-1]
ENST00000588693.5
K7ERE2
Q96A25
B7Z779
ENST00000541594.5 [Q96A25-2]